胰腺类癌的临床和病理学特点分析

 【目的】 探讨胰腺类癌的临床和病理学特点&;#65377;【方法】 对1997年1月1日至2007年12月31日期间手术治疗的8例胰腺类癌临床病理资料(如肿瘤标志物&;#65380;病理免疫组织化学染色&;#65380;伴发其他肿瘤&;#65380;误诊率&;#65380;肿瘤转移率&;#65380;住院死亡率&;#65380;手术根治率等)进行回顾性分析,并结合国内外文献探讨胰腺类癌的临床和病理学特点&;#65377; 【结果】 肿瘤标志物CEA&;#65380;CA199&;#65380;CA125&;#65380;CA72-4在胰腺类癌的表达阳性率分别为0%,25%,12.5%,0%,病理免疫组织化学染色Syn&;#65380;CgA&;#65380;NSE&;#65380;CK阳性率分别为25%,62.5%,75%,75%&;#65377;胰腺类癌伴发其他肿瘤为1/4&;#65377;胰腺类癌误诊率较高,8例患者中有7例误诊为其它肿瘤&;#65377;胰腺类癌肿瘤总的转移率为50%,住院死亡率为37.5%,而手术根治率为62.5%&;#65377; 【结论】 胰腺类癌误诊率高,常规血液肿瘤标志对早期发现胰腺类癌意义不大,确诊需要病理病理,临床预后较差&;#65377;

Clinical Pathological Characteristics in Pancreatic Carcinoid

Objective] To explore the clinical pathological characteristics and treatment of pancreatic careinoid. Methods] Eight patients with pancreatic careinoid were recruited between January in 1997 and December in 2007 for retrospective analysis which involved tumor markers, inanunohistostaining, accompanied with other tumors, misdiagnosis, metastasis, in-hospital mortality rate, and so on. The relevant literatures were simultaneously reviewed to comprehend the clinical pathological characteristics of pancreatic carcinoid. Results] Tumor markers CEA, CA199, CA125, and CA72-4 in pancreatic carcinoid were 0%, 25%, 12.5%, and 0%, respectively. Specimen immanohistostaining Syn, CgA, NSE, and CK in pancreatic carcinoid were 25%, 62.5%, 75%, and 75%, respectively. Two pancreatic carcinoids were accompanied by other tumors in 8 cases. The misdiagnosis rate of pancreatic carcinoid (7/8) was markedly high. Pancreatic carcinoid possessed high metastasis (50%), high in-hospital mortality rate (37.5%) and low radical operation undergone (62.5%). Conclusions] Pancrcatic carcinoid was accompanied with high misdiagnosis rate and poor prognosis. Routine sero-markers did not help discover pancreatic carcinoid early. The final diagnosis depended on specimen immunohistostaining with Syn, CgA, NSE, and CK.