屈光性弱视颜色视觉诱发电位的初步研究

【目的】 评价弱视的色觉损害以及颜色视觉诱发电位对弱视早期诊断和评价弱视儿童视功能的临床价值,探讨正常儿童、屈光不正性弱视儿童、屈光参差性弱视儿童的颜色视觉诱发电位的表现和差异。【方法】 应用同亮度不同颜色棋盘格的刺激,比较正常儿童、屈光不正性弱视儿童、屈光参差性弱视儿童的颜色视觉诱发电位。【结果】 受试者分为3组,分别为正常儿童组、屈光不正性弱视儿童组、屈光参差性弱视儿童组。①三组儿童组内比较发现:除绿/灰刺激后产生的P1波潜伏期比其它颜色刺激延长之外;其它颜色刺激产生的P1潜伏期两两间的差别无统计学意义。各种颜色刺激产生的P1-N2振幅在各组内的差异无统计学意义。②正常组和屈光不正组儿童在蓝/灰(P = 0.004)和蓝/黄刺激(P = 0.01)后的P1潜伏期的差别有统计学意义,而其它颜色刺激后的P1潜伏期没有显著差别;在红/灰刺激(P = 0.007)后的P1-N2振幅有显著差别,而其它颜色刺激后的P1-N2振幅没有显著差别。③正常组和屈光参差组儿童在蓝/灰(P = 0.02)和蓝/黄刺激(P = 0.01)后的P1潜伏期有显著差别,而其它颜色刺激后的P1潜伏期没有显著差别;正常组和屈光参差组儿童在红/灰(P = 0.005)和黑/白刺激(P = 0.009)后的P1-N2振幅有显著差别,而其它颜色刺激后的P1-N2振幅没有显著差别。④屈光不正组和屈光参差组儿童在各种不同颜色刺激后,两组之间的P1潜伏期及P1-N2没有显著差异 (P值均大于0.05)。【结论】 正常眼和弱视眼的颜色视觉诱发电位存在差异,而屈光不正性弱视和屈光参差性弱视之间则不存在差异。颜色视觉诱发电位可能有助于弱视的早期诊断和视功能评价。

Chromatic Pattern Visual Evoked Potential among Chinese Children with and without Amblyopia

【Objective】 To compare chromatic pattern visual evoked potential (VEP) outcomes among children with healthy eyes, children with refractive amblyopia, and children with anisometropic amblyopia. 【Methods】 Six types of chromatic pattern VEP tests were applied in the children. 【Results】 We examined children with healthy eyes (group 1), with refractive amblyopia (group 2), and with anisometropic amblyopia (group 3). There were no significant differences in P1 latencies and P1-N2 amplitudes among the six chromatic pattern VEP tests, except that the green-gray test had a longer P1 latency than the other tests. There were no significant differences in P1 latencies between group 1 and group 2, except for the one based on blue-gray (P = 0.004) and blue-yellow test (P = 0.01). There were no significant differences in P1-N2 amplitudes between group 1 and group 2, except for the one based on red-gray test (P =0.007). There were no significant differences in P1 latencies between group 1 and group 3, except for the one based on blue-gray (P =0.02) and blue-yellow test(P = 0.01). There were no significant differences in P1-N2 amplitudes between group 1 and group 3, except for the one based on red-gray test (P = 0.005) and black-white test (P = 0.009). There were no significant differences in P1 latencies and P1-N2 amplitudes between group 2 and group 3 (all with P > 0.05). 【Conclusions】 There are significant differences in P1 latencies and P1-N2 amplitudes between amblyopic eyes and healthy eyes, but no differences are noted between refractive amblyopic eyes and anisometropic amblyopic eyes. The chromatic pattern VEP may be useful to differentiate children with amblyopia.