| 单侧穹窿伞损伤对老年大鼠空间记忆及海马胆碱能纤维的影响 |
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| 引用本文： | 周丽华,姚志彬,陈以慈,邝国璧.单侧穹窿伞损伤对老年大鼠空间记忆及海马胆碱能纤维的影响[J].中山大学学报(医学科学版),1996(1). |
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| 作者姓名： | 周丽华 姚志彬 陈以慈 邝国璧 |
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| 作者单位： | 中山医科大学解剖学教研室脑研究室 |
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| 摘 要： | 对老年大鼠行单侧穹窿伞横断术，术后２周，用Ｍｏｒｒｉｓ水迷宫试验及乙酰胆碱酯酶（ＡｃｈＥ）染色观察大鼠的学习记忆及海马ＡｃｈＥ阳性纤维密度的变化。结果表明：海马ＣＡ１、ＣＡ３及齿状回的ＡｃｈＥ纤维明显减少，而且减少程度与学习记忆的下降成正相关关系。说明该模型既具有老年性痴呆的主要临床表现──学习记忆下降，另一部分模拟了该病的主要神经病理改变──基底前脑的胆碱能纤维溃变。
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| 关 键 词： | 海马／损伤，记忆障碍／病因学，痴呆老年性／病理学，胆碱能纤维／病理学，疾病模型，动物，大鼠 |
UNILATERAL TRANSECTION OF FIMBRIA-FORNIX AFFECTS THE SPATIAL MEMORY AND CHOLINERGIC INNERVATION OF THE HIPPOCAMPI OF AGED RATS |
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| Zhou Lihua, Yao Zhibin, Chen Yici, Kuang Guobi.UNILATERAL TRANSECTION OF FIMBRIA-FORNIX AFFECTS THE SPATIAL MEMORY AND CHOLINERGIC INNERVATION OF THE HIPPOCAMPI OF AGED RATS[J].Journal of Sun Yatsen University(Medical Sciences),1996(1). |
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| Authors: | Zhou Lihua Yao Zhibin Chen Yici Kuang Guobi |
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| Abstract: | he aged rats were tested in the Morris Water Maze and their hippocampi were stained with AchE two weeks after unilateral transection of the fimbria-fornix. The results showed that in lesioned rats the spatial memory were injuried. AchE positive fiber densities in CA1 , CA3 and dentate gyrus all decreased. The fiber density was in direct ratio to the level of memory. It concludes that this model not only provides with typical cholinergic degeneration , it shows the memory impairment ,too. |
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| Keywords: | hippocampus /injuries memory disorders/etiology dementia senile/ pathology cholinergic fibers/pathology disease model animal rats |
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