他司曲洛对实验性大鼠心衰模型的改善作用

目的 制备地龙β-环糊精包合物，改善其溶解性及去除不良气味。方法 以次黄嘌呤为指标，考察β-环糊精加入比例、温度及时间对包合工艺的影响，并进行包合物口感满意度及溶解性检测。结果 地龙（生药）-β-环糊精的比例为15∶1，70 ℃下超声处理60 min，次黄嘌呤平均包合率为80.31%，口感满意度为90%以上，溶解度有较大改善。结论 地龙β-环糊精包合工艺可行，并可有效解决地龙不良气味问题。

Improvement of tasiquluo on heart failure model of experimental rats

Objective To study the effect of astragaloside IV derivative tasiquluo used in the treatment of heart failure in experimental rat model. Methods To establish the congestive heart failure (CHF) in rats induced by ligation of the coronary artery. The animals were divided into Sham, model, teste, and positive control groups. Cumulative medication was used to study the positive inotropic effects of tasiquluo. The equivalent dosage (ED15), toxic dosage, and relative safety index were determined according to +LVdp/dtmax. Each group was iv administered with the equivalent dosage for 3 d. The effects and features in the treatment of the heart failure in rats for the short term were investigated by hemodynamics, color Doppler ultrasound echocardiogram, blood gas analysis, and pulmonary edema determination. Results The maximum effective dosage of Tasiquluo was 2 mg/kg, and 25% of the maximum effect could be generated. With ED15 iv infusion of tasiquluo for 3 d, the -LVdp/dtmax was significantly increased and the LVEDP was reduced. While the value of A peak lowered and E/A ratio increased, arterial blood oxygen pressure and oxygen content increased. At the same time, the edema of the lung tissue was relieved. Conclusion Tasiquluo has the good effects on experimental rat model with heart failure, and the drug could reach the positive inotropic effects to some extent. In addition, Tasiquluo could improve the cardiac diastolic functions, reduce the pulmonary edema, and improve the respiratory symptoms in rats with heart failure.