| 冰片和熊去氧胆酸对黄芩苷角膜透过性的影响 |
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| 引用本文： | 赵海南,李 琳,张 锐,李佳玮,张 倩,刘志东.冰片和熊去氧胆酸对黄芩苷角膜透过性的影响[J].医学教育探索,2013,44(2):153-157. |
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| 作者姓名： | 赵海南 李 琳 张 锐 李佳玮 张 倩 刘志东 |
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| 作者单位： | 1.天津中医药大学 天津市现代中药重点实验室-省部共建国家重点实验室培育基地，天津 300193 2.天津中医药大学 现代中药发现与制剂技术教育部工程研究中心，天津 300193 |
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| 基金项目： | 国家自然科学基金资助项目（81001645）；中国博士后科学基金（20090460701）；天津市自然科学基金项目（12JCYBJC18700） |
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| 摘 要： | 目的 研究冰片、熊去氧胆酸对黄芩苷离体角膜透过率的影响，探讨其在眼用制剂中的应用。方法 采用离体角膜渗透技术考察不同质量浓度的冰片、熊去氧胆酸对黄芩苷角膜透过率的影响。结果 0.2 mg/mL的冰片使黄芩苷表观渗透系数（Papp）增加了1.36倍，与对照组相比具有显著性差异（P＜0.05）；0.3、0.4、0.5、0.7 mg/mL的冰片使黄芩苷Papp分别增加了1.35、1.43、1.51、3.47倍，0.2、0.3、0.4、0.5、0.7 mg/mL的熊去氧胆酸使黄芩苷Papp分别增加了1.19、2.25、1.24、0.35、0.68倍，与对照组相比均具有非常显著性差异（P＜0.01）。结论 0.2、0.3、0.4、0.5、0.7 mg/mL的冰片、熊去氧胆酸能够显著增大黄芩苷的Papp，且对角膜无刺激性。
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| 关 键 词： | 冰片 熊去氧胆酸 角膜透过性 黄芩苷 离体角膜渗透技术 |
Effects of borneol and ursodesoxycholic acid on corneal permeability of baicalin |
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| ZHAO Hai-nan,LI Lin,ZHANG Rui,LI Jia-wei,ZHANG Qian,LIU Zhi-dong.Effects of borneol and ursodesoxycholic acid on corneal permeability of baicalin[J].Researches in Medical Education,2013,44(2):153-157. |
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| Authors: | ZHAO Hai-nan LI Lin ZHANG Rui LI Jia-wei ZHANG Qian LIU Zhi-dong |
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| Institution: | 1.Tianjin State Key Laboratory of Modern Chinese Medicine, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China 2.Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China |
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| Abstract: | Abstract: Objective To investigate the effects of borneol and ursodesoxycholic acid on the corneal permeability of baicalin in vitro, and to discuss their application in ocular preparation. Methods The effects of borneol and ursodesoxycholic acid with different concentration on the corneal permeability of baicalin were investigated in vitro using the isolated corneal penetration technology. Results Borneol (0.2 mg/mL) could significantly increase the apparent permeability (Papp) of baicalin in 1.36-fold compared with the control group (P < 0.05). Borneol (0.3, 0.4, 0.5, and 0.7 mg/mL) could increase the Papp of baicalin in 1.35-, 1.43-, 1.51-, and 3.47-folds, respectively, and ursodesoxycholic acid (0.2, 0.3, 0.4, 0.5, and 0.7 mg/mL) could significantly increase the Papp of baicalin in 1.19-, 2.25-, 1.24-, 0.35-, and 0.68-folds, respectively compared with the control group (P < 0.01). Conclusion Borneol and ursodesoxycholic acid (0.2, 0.3, 0.4, 0.5, and 0.7 mg/mL) could significantly increase the Papp of baicalin without stimulation on rabbit cornea. |
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| Keywords: | borneol ursodesoxycholic acid corneal permeability baicalin in vitro corneal penetration technology |
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