| 鲤鱼精巢DNA抗脂质过氧化作用研究 |
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| 引用本文： | 唐孝礼,周永红.鲤鱼精巢DNA抗脂质过氧化作用研究[J].医学教育探索,1999(10):755-757. |
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| 作者姓名： | 唐孝礼 周永红 |
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| 作者单位： | [1]中山医科大学药理学教研室 [2]广东药学院预防医学系卫化室 |
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| 摘 要： | 鲤鱼精巢ＤＮＡ对组织奖浆自发的或由Ｆｅ＾２＿－Ｃｙｓｔｅｉｎｅ体系激的脂质过氧化作用均有显著的抑制作用，在０．１６￣１００μｇ／ｍＬ浓度范围内有明显的剂量依赖关系；小鼠ｉｇＤＮＡ１５ｄ，其脑、心、肝中丙三醛生成量明显减少，小鼠ｉｇＤＮＡ４５ｄ，其脑和肝脏中的脂褐素含量明显低于空白对照组。
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| 关 键 词： | 鲤鱼精巢 DNA 脂质过氧化 脂褐素 |
Studies on the Anti-lipid Peroxidation of DNA from Carp Spermary |
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| Tang Xiaoli,Zhou Yonghong,Xu Shibo,et al.Studies on the Anti-lipid Peroxidation of DNA from Carp Spermary[J].Researches in Medical Education,1999(10):755-757. |
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| Authors: | Tang Xiaoli Zhou Yonghong Xu Shibo |
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| Institution: | Department of Pharmacology Sun Yat-sen Universityof Medical Sciences GuangZhou 510089 |
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| Abstract: | The andti-lipid peroxidation effect of deoxyribonucleic acid from carp spermary(CSDNA)was studied Results of the study showed that CSDNA could markedly inhibit either spontaneous lipid peroxi-dation or that induced by Fe~(2 ) -Cysteine system in tissue homogenates in a dose-dependent manner within therange of 0.16~100g/mL MDA content in the brain ,heart and liver of mice reduced obviously after ig administration of CSDNA for 15d Lipofuscinlevels in the brain and liver of mice were significantly lowered after ig administration of CSDNA for 45 d as compared with the control |
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| Keywords: | carp spermary deoxyribonucleic acid lipid peroxidation lipofuscin |
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