活体肿瘤成像技术的研究进展

成像技术在肿瘤生物学研究和临床诊断治疗中是不可或缺的工具之一，活体动物成像实验平台的主要优点是无创伤、低成本、实时检测，而分子探针与活体荧光成像技术相结合对肿瘤的早期诊断具有重要意义。肿瘤的近红外荧光（NIRF）成像技术依赖于稳定、高特异性和敏感性的分子探针。综述活体肿瘤成像技术的研究进展以及该项技术与新的分子探针、显像剂、报告分子的协同作用，为进一步应用于临床肿瘤诊断和治疗打下基础。

Advances in studies on in vivo imaging of cancer

Imaging technology is one of the indispensable tools in oncobiological research and clinical diagnosis and therapy. The imaging experimental platform of in vivo animals has several advantages such as non-invasion, low cost, and real-time detection, and the combination of molecular probe and in vivo fluorescence imaging technique plays an important role in the early diagnosis of tumor. Near-infrared fluorescence (NIFR) imaging of tumor depends on the molecular probes with stability, high-specificity, and sensitivity. In the present paper, the research advance of in vivo tumor imaging and its synergism with novel molecular probes, imaging reagents, and reporters are summarized so as to lay a foundation on applicating it in clinical diagnosis and therapy of tumor.