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具有内皮祖细胞捕获功能的聚氨酯的合成与研究
引用本文:陆跃,贾建国,龚飞荣,饶炬,陈建定,程树军.具有内皮祖细胞捕获功能的聚氨酯的合成与研究[J].医学教育探索,2010(5):668-673.
作者姓名:陆跃  贾建国  龚飞荣  饶炬  陈建定  程树军
作者单位:华东理工大学材料科学与工程学院,超细材料制备与应用教育部重点实验室,上海 200237;复旦大学附属中山医院,上海市心血管病研究所,上海 200232;华东理工大学材料科学与工程学院,超细材料制备与应用教育部重点实验室,上海 200237;华东理工大学材料科学与工程学院,超细材料制备与应用教育部重点实验室,上海 200237;华东理工大学材料科学与工程学院,超细材料制备与应用教育部重点实验室,上海 200237;华东理工大学材料科学与工程学院,超细材料制备与应用教育部重点实验室,上海 200237
基金项目:国家自然科学基金(30870622);国家863项目(2007AA02Z450)
摘    要:以聚碳酸酯二元醇(PCDL)为软段,1,6-六亚甲基二异氰酸酯(HDI)为硬段,二羟甲基丙酸(bis-MPA)为扩链剂合成了一种侧 链含有羧基官能团的聚碳酸酯型聚氨酯材料。将氨基封端的四代树枝状聚酯大分子共价接枝到聚氨酯的侧链上,脱除树枝状分子表 面缩酮保护基后得到了一种新型的侧链树枝化多羟基聚氨酯材料。此聚合物能有效黏附CD133抗体,黏附了抗体的材料可大大提高 CD133内皮祖细胞的黏附。这一结果为通过加速血液接触材料表面内皮化来提高其血液相容性提供了可能。

关 键 词:聚氨酯    树枝状大分子    CD133抗体    内皮祖细胞

Synthesis and Study of Endothelial Progenitor Cells Capturing Polyurethane
LU Yue,JIA Jian-guo,GONG Fei-rong,RAO Ju,CHEN Jian-ding and CHENG Shu-jun.Synthesis and Study of Endothelial Progenitor Cells Capturing Polyurethane[J].Researches in Medical Education,2010(5):668-673.
Authors:LU Yue  JIA Jian-guo  GONG Fei-rong  RAO Ju  CHEN Jian-ding and CHENG Shu-jun
Institution:Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China;Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital Fudan University, Shanghai 200232, China;Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China;Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China;Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China;Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China
Abstract:A novel side chain dendronized polyhydric polyurethane was synthesized by sequential conjugation of amine -terminated fourth generation polyester dendrons with pendent carboxyl groups of polyurethane and deprotection of acetonide groups at the surface of dendrons. The polyurethane base polymer was synthesized using PCDL as soft segments, HDI as hard segments, and bis-MPA as chain extenders. The polyhydric polyurethane was used to immobilize CD133 antibody by hydrogen bonding. Endothelial progenitor cells (EPC) attachment was significantly enhanced on the surfaces of the CD133 antibody immobilized polyurethane, which may be contribute to improve the hamoecompatibility of the blood contacting materials by quick endothelialization.
Keywords:polyurethane  dendrimers  CD133 antibody  progenitor cell
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