丹参注射液和盐酸左氧氟沙星注射液在5%葡萄糖注射液中的不溶性微粒变化情况分析

目的 观察丹参注射液、盐酸左氧氟沙星注射液分别溶于5%葡萄糖注射液中不溶性微粒随溶液pH值的改变而变化的情况。方法 利用微粒分析仪测定2种注射液分别与5%葡萄糖注射液的混合溶液及混合溶液随pH值变化的微粒数。结果 与5%葡萄糖注射液混合后，在pH值较低时，丹参注射液的不溶性微粒明显增加，盐酸左氧氟沙星注射液的不溶性微粒增加不明显。结论 丹参注射液不宜与其他药物在同一容器中混合使用，不宜与较低pH值的葡萄糖注射液配伍；盐酸左氧氟沙星注射液可与5%葡萄糖注射液配伍使用。

Analysis on insoluble particles changing of Danshen Injection and Levofloxacin Hydrochloride Injection in 5% glucose injection

Objective To observe the insoluble particles variation of Levofloxacin Hydrochloride and Danshen Injection dissolved in 5% glucose injection, respectively, with the changing of pH value. Methods Using particle analyzer to determine the quantity of insoluble particles in the mixture of the two injections in 5% glucose injection, and also test the amount variation of insoluble particles with the changing of pH value. Results Mixed with 5% glucose injection, when pH value is lower, the amount of insoluble particles was significantly increased in Danshen Injection. On the other hand, there was no significant increase of insoluble particles in Levofloxacin Hydrochloric Injection. Conclusion Danshen Injection should not be mixed with other drugs in use, or mixed with glucose injection in the lower pH value; while Levofloxacin Hydrochloride Injection can be used with 5% glucose injection.