| 口服缓释制剂体内外相关性评价方法研究进展 |
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| 引用本文： | 王 维,王 博,连潇嫣,李洪起,任晓文.口服缓释制剂体内外相关性评价方法研究进展[J].医学教育探索,2011,34(5):380-383. |
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| 作者姓名： | 王 维 王 博 连潇嫣 李洪起 任晓文 |
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| 作者单位： | 1.天津中医药大学，天津 300193 2.天津药物研究院 释药技术与药代动力学国家重点实验室，天津 300193 |
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| 基金项目： | 国家重点基础研究发展计划项目（2010CB735602） |
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| 摘 要： | 对近年国内外文献中有关口服缓释制剂体外溶出度测定的试验方法和条件、体内评价的相关方法、体内外相关性研究进行了综述。根据药物的不同性质选择尽可能接近体内环境的试验方法，建立较好的体内外相关性，对口服缓释制剂的研究具有重要意义。
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| 关 键 词： | 口服缓释制剂 溶出度 体内评价 体内外相关性 |
In vivo-in vitro correlation of sustained-release oral dosage forms |
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| WANG Wei,WANG Bo,LIAN Xiao-yan,LI Hong-qi,REN Xiao-wen.In vivo-in vitro correlation of sustained-release oral dosage forms[J].Researches in Medical Education,2011,34(5):380-383. |
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| Authors: | WANG Wei WANG Bo LIAN Xiao-yan LI Hong-qi REN Xiao-wen |
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| Institution: | 1.Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China 2.State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China |
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| Abstract: | To summarize all current literatures about the methods and test factors of dissolution and the evaluation of in vivo-in vitro correlation of sustained release oral dosage forms. According to the different nature of drugs, selecting the method could create a better in vivo condition and establish a better in vivo-in vitro correlation, which is important for the research on sustained release. |
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| Keywords: | sustained-release oral dosage forms dissolution in vitro evaluation in vitro-in vivo correlation |
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