Tecarfarin |
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Authors: | LIU Hong-qiang CAI Zhi-qiang LIU Ju WANG Yang ZHANG Wei-guang XU Wei-ren TANG Li-da and SHEN Xiu-ping |
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Institution: | Tianjin Chasesun Pharmaceutical Co., Ltd., Tianjin 301700, China;Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China;Tianjin Chasesun Pharmaceutical Co., Ltd., Tianjin 301700, China;Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China |
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Abstract: | Objective To design and synthesize antibacterial derivatives containing isoxazoline. and to evaluate their antibacterial activities. Methods The target compounds were synthesized with the starting material 3, 4-difluoro-benzaldehy with hydroxylamine hydrochloride. And their antibacterial activities have been tested in vitro with linezolide as positive control. Results Nine target compounds were synthesized and their structures were confirmed by 1H-NMR, MS. The pharmacological tests showed that one of the tested compounds exhibited novel antibacterial activity compared with linezolide. Conclusion The structure-activity relationships of isoxazoline derivatives, as a novel antibaterial type, should be further investigated. |
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Keywords: | isoxazoline derivatives 3 4-difluoro-benzaldehy linezolide antibacterial activity |
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