清肺消炎丸体外抗菌活性研究

目的 观察清肺消炎丸对9种肺炎常见病原菌的体外抗菌作用。方法 采用琼脂稀释法，测定清肺消炎丸对9种药敏质控菌株的最低抑菌浓度（MIC）及最低杀菌浓度（MBC）。结果 清肺消炎丸对肺炎链球菌、化脓性链球菌、金黄色葡萄球菌、流感嗜血杆菌的MIC分别为6.25、25、25、50 mg/mL，相应的MBC分别为12.5、25、50、50 mg/mL；对大肠杆菌、铜绿假单胞菌、肺炎克雷伯菌、变形杆菌及白色念珠菌均无明显体外抑菌活性。结论 清肺消炎丸对肺炎链球菌、化脓性链球菌、金黄色葡萄球菌、流感嗜血杆菌具有体外抗菌作用，其中对链球菌的抗菌活性较高。

Antibacterial activity of Qingfei Xiaoyan Pills in vitro

Objective To study the antibacterial effect of Qingfei Xiaoyan Pills. Methods By using test agar plates serial dilution method, the minimum inhibition concentration (MIC) and minimal bactericidal concentration (MBC) of different dilution degrees of Qingfei Xiaoyan Pills on Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumonia, Streptococcus pneumoniae, Escherichia coli, Proteusbacillus vulgaris, Haemophilus influenza, Streptococcus pyogeones, and Canidia albicans were determined. Results The MICs of Qingfei Xiaoyan Pills to Streptococcus pneumoniae, Streptococcus pyogeones, Staphylococcus aureus, and Haemophilus influenza were 6.25, 25, 25 and 50 mg/mL, respectively, while the MBCs were 12.5, 25, 50 and 50 mg/mL, respectively. Conclusion Qingfei Xiaoyan Pills could effectively inhibit Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogeones and Haemophilus influenza. Among them, Qingfei Xiaoyan Pills are more effective for Streptococcus.