| Anti-diabetic Activity of Zhenqing Recipe and Ligustri Lucidi Fructus in Type 2 Diabetic Rats |
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| 作者姓名： | WEN Xiu-ying XU Wen-guang XIONG Ling XU Ming-wang LIU Hao ZHANG Hong LUO Qiong NIAO Qiu-hong LIU Li-fang |
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| 作者单位： | Liyuan Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430077, China;Liyuan Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430078, China;Liyuan Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430079, China;Liyuan Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430080, China;Liyuan Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430081, China;Liyuan Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430082, China;General Hospital of the Yangtze River shipping, Wuhan 430015, China;Liyuan Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430077, China;The Central Hospital of Ezhou City, Ezhou 436000, China |
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| 摘 要： | Objective To investigate the influence of Zhenqing Recipe (ZQR) and Ligustri Lucidi Fructus (LLF) on diabetic rats and its possible mechanism. Methods The model of type 2 diabetic rats was established by feeding a high-sucrose-high-fat diet and injecting a low dose of Streptozotocin in Wistar rats. The model rats were randomly divided into three groups: diabetic model, ZQR-treated, and LLF-treated groups for 8-weeks treatment. The normal Wistar rats were as a normal control group. Results The level of fasting blood glucose in ZQR and LLF groups was decreased compared with model group (P < 0.01, 0.05, respectively). Both ZQR and LLF markedly reduced serum triglycerides (P < 0.01, 0.05, respectively), and increased the insulin sensitivity index (P < 0.05). Histopathology revealed that ZQR and LLF reduced pancreatic damage. Immunohistochemistry evaluation showed that the percentage of insulin positive cells in pancreatic island was higher than model group (P < 0.01, 0.05, respectively).The mRNA and protein expression of SREBP-1c in pancreas were significantly decreased in ZQR and FLL group (P < 0.01). Conclusion ZQR has therapeutic effect on type 2 diabetes, it ameliorates the histopathological changes of pancreas, protects β cells, improves insulin resistance, and attenuates the expression of SREBP-1c. This study also provides the anti-diabetic evidence of FLL even its effects are weaker than ZQR.
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Anti-diabetic Activity of Zhenqing Recipe and Ligustri Lucidi Fructus in Type 2 Diabetic Rats |
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| WEN Xiu-ying,XU Wen-guang,XIONG Ling,XU Ming-wang,LIU Hao,ZHANG Hong,LUO Qiong,NIAO Qiu-hong,LIU Li-fang.Anti-diabetic Activity of Zhenqing Recipe and Ligustri Lucidi Fructus in Type 2 Diabetic Rats[J].Researches in Medical Education,2011,3(1):47-53. |
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| Authors: | WEN Xiu-ying XU Wen-guang XIONG Ling XU Ming-wang LIU Hao ZHANG Hong LUO Qiong NIAO Qiu-hong and LIU Li-fang |
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| Abstract: | |
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| Keywords: | insulin-producing cells Ligustri Lucidi Fructus SREBP-1c type 2 diabetes rats Zhenqing Recipe |
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