| 药物肠道吸收研究方法 |
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| 引用本文： | 祝诚诚,何 新.药物肠道吸收研究方法[J].医学教育探索,2010,33(3):222-227. |
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| 作者姓名： | 祝诚诚 何 新 |
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| 作者单位： | 1 天津中医药大学 中药学院，天津 300193； 2 教育部方剂学重点实验室，天津 300193； 3 天津市中药化学与分析重点实验室，天津 300193 |
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| 基金项目： | 国家重大新药创制专项(编号2009ZX09304-002)、国家自然科学基金(编号30772778)国家高等学校博士学科点专项科研基金 (编号200800630005)、国家中医药管理局中医药行业科研专项(编号200807051)资助。 |
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| 摘 要： | 药物在肠道内的吸收程度和吸收特征是影响口服药物生物利用度的重要因素。肠道吸收研究可以预测影响药物在肠道吸收的机制与因素，研究方法主要包括体内法（in vivo）、在体法（in situ）、体外法（in vitro）等。就目前药物小肠吸收的研究方法及其特点进行综述。
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| 关 键 词： | 肠吸收 在体肠灌流法 外翻肠囊法 Ussing chamber 细胞培养模型法 药物溶出/吸收动态仿生系统法（DDASS） |
Methodology study of drug intestinal absorption |
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| ZHU Cheng-cheng,HE Xin.Methodology study of drug intestinal absorption[J].Researches in Medical Education,2010,33(3):222-227. |
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| Authors: | ZHU Cheng-cheng HE Xin |
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| Institution: | 1 College of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China 2 Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae,Ministry of Education, (Tianjin University of Traditional Chinese Medicine) Tianjin 300193, China; 3 Tianjin Key Laboratory of TCM Chemistry and Analysis, Tianjin 300193, China |
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| Abstract: | The degree and character of intestinal tract absorption is an important factor that affects bioavailability of oral drugs. The absorption study of intestinal tract, including in vivo, in situ, in vitro ,and so on, can predict mechanisms and factors that affect drug absorption in intestine. In this paper, the current methods of drug intestinal absorption and their characteristics are reviewed. |
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| Keywords: | intestinal absorption intestinal perfusion everted gut sacs Ussing chamber cell models drug dissolution/absorption simulating system (DDASS) |
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