| 聚合物刷与生物分子相互作用的研究进展 |
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| 引用本文： | 王思怿,郭旭虹,陈凯敏.聚合物刷与生物分子相互作用的研究进展[J].医学教育探索,2016,29(4):359-376. |
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| 作者姓名： | 王思怿 郭旭虹 陈凯敏 |
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| 作者单位： | 上海化工研究院检测中心, 上海 200062,华东理工大学化工学院, 化学工程联合国家重点实验室, 上海 200237,上海工程技术大学化学化工学院, 上海 201620 |
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| 基金项目： | 国家自然科学基金（21504052）；上海市青年科技英才扬帆计划（15YF1404800） |
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| 摘 要： | 聚合物刷是由一端紧密接枝在一个曲面或平面的聚合物链组成的大分子结构。近年来，随着聚合物制备方法和表面修饰技术的不断发展，聚合物刷的应用范围也在不断拓宽，相关研究已成为功能高分子材料领域的热点之一。具有特殊结构和功能的聚合物刷在生物分子固定、蛋白质分离、酶催化、药物控释等方面具有广阔的应用前景。本文综述了聚合物刷与生物分子相互作用及应用的最新研究进展，并展望了今后的发展方向。
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| 关 键 词： | 聚合物刷 生物分子 相互作用 蛋白固定化 酶催化 |
| 收稿时间： | 2016/8/24 0:00:00 |
Progress in Interaction between Polymer Brushes and Biomolecules |
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| WANG Si-yi,GUO Xu-hong and CHEN Kai-min.Progress in Interaction between Polymer Brushes and Biomolecules[J].Researches in Medical Education,2016,29(4):359-376. |
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| Authors: | WANG Si-yi GUO Xu-hong and CHEN Kai-min |
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| Institution: | Testing Center, Shanghai Research Institute of Chemical Industry, Shanghai 200062, China,State Key Laboratory of Chemical Engineering, School of Chemical Engineering, East China University of Science and Technology, Shanghai 200237, China and College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai 201620, China |
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| Abstract: | Polymer brush is a structure with polymer chains attached with one end to a curved or planar surface.In recent years,with the development of polymer preparation methods and surface modification technology,the application range of polymer brush is continuously expanded.Relevant researches of polymer brush become one of the hotpots in the area of functional polymeric materials.Polymer brushes with unique structure and surface properties become suitable candidates in the application of biomolecule immobilization,protein separation,enzymatic catalyst and controlled drug delivery.In this review,the latest progress in interactions between polymer brushes and biomolecules is systematically described,and some possible directions for further research are forecasted. |
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| Keywords: | polymer brush biomolecule interaction protein immobilization enzymatic catalyst |
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