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培菲康治疗前后肠易激综合征患者相关肠道益生菌群变化分析
引用本文:崔舒晟,胡颖.培菲康治疗前后肠易激综合征患者相关肠道益生菌群变化分析[J].徐州医学院学报,2010,30(1):45-48.
作者姓名:崔舒晟  胡颖
作者单位:1. 黄浦区中心医院肿瘤内科,上海,200002
2. 上海交通大学医学院附属新华医院消化内科,上海,200092
摘    要:目的观察培菲康治疗前后肠易激综合征(IBS)患者肠道相关益生菌群的变化。方法选取符合罗马Ⅲ标准的IBS患者60例及年龄、性别相匹配的对照人群20人,IBS患者包括腹泻型、便秘型、混合型、未分型4种类型,再将IBS患者随机分为2亚组,治疗组予以培菲康治疗,2片,3次/d,疗程为4周,对照组予以安慰剂治疗4周,比较治疗前后患者粪便中双歧杆菌和乳杆菌数量的变化。结果腹泻型IBS患者粪便中双歧杆菌及乳杆菌含量均小于正常人群(P〈0.01),混合型IBS患者粪便中双歧杆菌含量小于正常人群(P〈0.01);服用培菲康4周后,患者粪便中双歧杆菌及乳杆菌含量均高于治疗前(P〈0.01);以腹泻为主的IBS患者中,治疗有效者,治疗后粪便中双歧杆菌和乳杆菌含量都要少于治疗无效者(P〈0.01)。结论IBS患者存在某种肠道菌群的量的变化,且外源性补充相关益生菌制剂时,患者病情的变化伴有粪便中益生菌群的变化。

关 键 词:肠易激综合征  益生菌  荧光定量PCR  肠道菌群

Analysis of the variations of fecal probiotic microbiota in patients with irritable bowel syndrome before and after treatment with bifid triple viable capsules
CUI Shusheng,HU Ying.Analysis of the variations of fecal probiotic microbiota in patients with irritable bowel syndrome before and after treatment with bifid triple viable capsules[J].Acta Academiae Medicinae Xuzhou,2010,30(1):45-48.
Authors:CUI Shusheng  HU Ying
Institution:CUI Shusheng1,HU Ying2(1.Department of Oncology,Huangpu District Central Hospital,Shanghai 200002,China,2.Department of Gastroenterology,Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine,Shanghai 200092,China)
Abstract:Objective To analysis of the fecal Bifidobacterium spp.and Lactobacillus spp.in patients with irritable bowel syndrome(IBS) before and after treatment with bifid triple viable capsules for 4 weeks.Methods 60 participants with IBS,as defined by the Rome III criteria,were compared with age-and gender-matched control subjects(n=20).The IBS patients were divided into diarrhea group,constipation group,alternating group and unclassified group.The patients in the diarrhea and constipation groups were further divid...
Keywords:irritable bowel syndrome  probiotics  fluorescent Real-time PCR  gut microbiota  
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