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东莨菪碱、黄芪合用对小鼠吗啡精神依赖性的影响
引用本文:田振,徐振华,刘威,臧婷,王进龙,圣春平,周苏,戴体俊,王丹.东莨菪碱、黄芪合用对小鼠吗啡精神依赖性的影响[J].徐州医学院学报,2010,30(2):75-76.
作者姓名:田振  徐振华  刘威  臧婷  王进龙  圣春平  周苏  戴体俊  王丹
作者单位:1. 徐州医学院麻醉学院麻醉学专业2006级2班,江苏,徐州,221002
2. 徐州医学院临床一系2006级6班
3. 徐州医学院麻醉药理学教研室,江苏,徐州,221002
基金项目:国家自然科学基金,江苏省自然科学基金 
摘    要:目的观察东莨菪碱、黄芪合用对吗啡依赖小鼠精神依赖性的影响。方法昆明种小鼠30只,按分层随机区组设计分为3组:东莨菪碱组(D组)、黄芪组(H组)、东莨菪碱+黄芪组(DH组)。前3天上午小鼠皮下注射吗啡后立即放入偏爱器的白室30min,下午按分组分别皮下注射东莨菪碱、黄芪、东莨菪碱+黄芪30min后放入黑室30min,第4天将小鼠放人偏爱器中,记录15min内小鼠在白室的停留时间。结果DH组在白室停留时间明显短于D组和H组(P〈0.05)。结论东莨菪碱和黄芪合用较分别单用对小鼠条件性位置偏爱形成的抑制作用更显著,即二者合用对抑制小鼠吗啡精神依赖性的形成有协同作用。

关 键 词:东莨菪碱  黄芪  吗啡  条件性位置偏爱  精神依赖性  小鼠

The effect of scopolamine and astragalus on the morphine-induced psychic dependence in mice
TIAN Zhen,XU Zhenhua,LIU Wei,ZANG Ting,WANG Jinlong,SHENG Chunping,ZHOU Su,DAI Tijun,WANG Dan.The effect of scopolamine and astragalus on the morphine-induced psychic dependence in mice[J].Acta Academiae Medicinae Xuzhou,2010,30(2):75-76.
Authors:TIAN Zhen  XU Zhenhua  LIU Wei  ZANG Ting  WANG Jinlong  SHENG Chunping  ZHOU Su  DAI Tijun  WANG Dan
Institution:TIAN Zhen1,XU Zhenhua1,LIU Wei1,ZANG Ting1,WANG Jinlong1,SHENG Chunping1,ZHOU Su2,DAI Tijun3,WANG Dan3 (1.Class 2 of Anesthesiology Major,Grade 2006,School of Anesthesiology,Xuzhou Medical College,Xuzhou,Jiangsu 221002,China,2.Class 6 of The First Department of Clinical Medicine,3.Department of Anesthetic Pharmacology,Xuzhou Medical College)
Abstract:Objective To investigate the combined effects of scopolamine and astragalus on the morphine-induced psychic dependence in mice.Methods 30 Kunming mice were divided into 3 groups(n=10 each) by stratified randomization: scopolamine group(group D),astragalus group(group H) and scopolamine+astragalus group(group DH).For the first 3 days,in the morning all groups were kept for 30 min in a white box immediately after subcutaneous injection of morphine,and in the afternoon,30 min after injection of the same volume...
Keywords:scopolamine  astragalus  morphine  conditioned place preference  psychic dependence  mice  
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