| 改良二袖套法大鼠小体积肝移植模型的建立 |
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| 引用本文： | 宋军,华志元,姚爱华,浦立勇,王学浩.改良二袖套法大鼠小体积肝移植模型的建立[J].徐州医学院学报,2008,28(1):35-38. |
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| 作者姓名： | 宋军 华志元 姚爱华 浦立勇 王学浩 |
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| 作者单位： | 南京医科大学第一附属医院肝脏移植中心,江苏,南京,210029 |
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| 基金项目： | 国家自然科学基金（30671992） |
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| 摘 要： | 目的 探讨建立稳定的小体积(30%)大鼠肝移植模型的方法.方法 SD大鼠为模型动物,体内切肝方法获取30%小体积供肝,采用改良二袖套法共完成100例大鼠小体积肝移植模型.结果 小体积肝移植术后,受体2天和7天生存率分别为78%和62%.结论 采用改良二袖套法结合体内切肝技术,可以建立稳定的小体积大鼠肝移植模型.熟练的显微外科技术和细致的操作是成功建立小体积大鼠肝移植模型的关键.
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| 关 键 词： | 肝移植 小体积 动物模型 大鼠 改良 二袖套法 大鼠 小体积供肝 肝移植模型 model liver transplantation size small establishment technique 操作 显微外科技术 结合体 生存率 受体 肝移植术后 结果 法共 切肝 |
| 文章编号： | 1000-2065（2008）01-0035-04 |
| 收稿时间： | 2007-11-27 |
| 修稿时间： | 2008-01-07 |
A modified two - cuff technique in the establishment of rat small - for - size liver transplantation model |
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| SONG Jun,HUA Zhiyuan,YAO Aihua,PU Liyong,WANG Xuehao.A modified two - cuff technique in the establishment of rat small - for - size liver transplantation model[J].Acta Academiae Medicinae Xuzhou,2008,28(1):35-38. |
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| Authors: | SONG Jun HUA Zhiyuan YAO Aihua PU Liyong WANG Xuehao |
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| Abstract: | Objective To investigate the method of establishing a reliable 30% small - for - size liver transplantation model in rats. Methods SD rats were used in the experiment ; 30% small - for - size grafts were obtained by hepatectomy ; 100 models of 30% small - for - size rat liver transplantation were established by using modified two - cuff technique. Results 2 - and 7 - day survival rates were 78% and 62% respectively. Conclusion The modified two - cuff technique plus hepatectomy in vivo is a practical and effective method to establish stable small - for - size liver transplantation models in rats. Skillful microsurgery and meticulous manipulation is the key to successful establishment of the model. |
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| Keywords: | liver transplantation small - for - size animal model rat |
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