| 色甘酸二钠注射给药的毒性研究 |
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| 引用本文： | 陈锦明,吴文漪.色甘酸二钠注射给药的毒性研究[J].徐州医学院学报,1989,9(4):250-253. |
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| 作者姓名： | 陈锦明 吴文漪 |
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| 作者单位： | 徐州医学院药理学教研室
(陈锦明)，徐州医学院传染病学教研室(吴文漪) |
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| 摘 要： | 小白鼠iv DSCG的LD_(50)为2800±17.8mg/kg在猫与兔的急性毒性实验中,DSCG可引起短暂心率加快和血压升高,对ECG与呼吸几无影响。在亚急性毒性实验中,大剂量的DSCG可引红、白细胞数减少、肝功能损伤、肺间质性炎症和脾淤血。
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| 关 键 词： | 色甘酸二钠 急性毒性 亚急性毒性 |
THE TOXICITY STUDY OF INJECTED DISODIUM CROMOGLYCATE |
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| Chen Jinming.THE TOXICITY STUDY OF INJECTED DISODIUM CROMOGLYCATE[J].Acta Academiae Medicinae Xuzhou,1989,9(4):250-253. |
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| Authors: | Chen Jinming |
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| Abstract: | Disoium cromoglycate(DSCG)is believed to act by stabilizing the membrane of mast cells. In mice, the iv LC50 of DSCG was 2800 172.8mg/kg. In anesthetized cats and rabbits, intravenous injections of 2-30 ma/kg caused transient increase of heart rate and elevation of blood pressure, but no toxic effects were observed in ECG and respiration. Subacute experiments on rats and dogs showed DSCG 10-80 mg/kg decreased the numbers of RBC and WBC, affected liver functions and caused pulmonary interstitial inflammation |
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| Keywords: | disodium cromoglycate acute toxicity subacute toxicity |
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