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| 大肠癌CD133（＋）、Musashi-1（＋）干细胞与临床病理学因素及MGMT、ERCC1、TS关系的研究 | |
| 引用本文： | 程慧敏,刘静,唐采白,李彬,陈卫花,李龙飞.大肠癌CD133（＋）、Musashi-1（＋）干细胞与临床病理学因素及MGMT、ERCC1、TS关系的研究[J].徐州医学院学报,2010,30(2):104-110. |
| 作者姓名： | 程慧敏 刘静 唐采白 李彬 陈卫花 李龙飞 |
| 作者单位： | 1. 徐州医学院病理学教研室,江苏,徐州,221002;徐州医学院附属第三医院病理科,江苏,徐州,221004 2. 徐州医学院附属第三医院消化内科 3. 徐州医学院第二附属医院病理科,江苏,徐州,221006 |
| 基金项目： | 江苏省高校自然科学基金 |
| 摘 要： | 目的探讨大肠癌CD133（＋）、Musashi-1（＋）干细胞与临床病理因素及MGMT、ERCC1、TS的关系。方法应用免疫组织化学方法（SP法）检测42例大肠癌组织的CD133、CD138、Musashi-1、MGMT、ERCC1、TS蛋白,对各指标之间的相关关系及其与临床病理学因素之间的关系进行分析。结果①CD133与组织类型、Dukes分级、静脉侵袭、远处转移及毛细血管密度（MVD）等有关（P〈0.05）;CD138、Musachi-1与组织类型、浆膜侵犯、静脉侵袭、淋巴管侵袭、淋巴结转移、远处转移及MVD等有关（P〈0.05）,CD138并与神经纤维间隙侵袭（NI）有关（P〈0.05）;CD133与CD138的表达呈负相关（P〈0.01）,与Musashi-1的表达呈正相关（P〈0.01）。②MG-MT、ERCC1与组织类型有关（P〈0.05）;TS与组织类型、Dukes分级、淋巴管侵袭、淋巴结转移有关（P〈0.05）;MGMT表达与ERCC1、TS表达呈负相关（P〈0.01）,ERCC1表达与TS表达呈正相关（P〈0.01）。③CD133、Mu-sashi-1的表达均与MGMT的表达呈负相关（P〈0.01）,与TS、ERCC1的表达呈正相关（P〈0.01）。结论①CD133（＋）、Musashi-1（＋）细胞在大肠癌的浸润与转移中起重要协同作用。②CD133（＋）、Musashi-1（＋）细胞与MGMT、TS、ERCC1耐药基因蛋白的表达具有密切关系,后者在大肠癌的侵袭中也具重要作用。 |
| 关 键 词： | 大肠癌干细胞 CD133 Musashi-1 CD138 MGMT ERCC1 TS |
Research on the relationship between colorectal cancer stem cells CD133(+) and Musashi-1(+) and clinical pathologic factors as well as proteins MGMT,ERCC1 and TS |
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| CHENG Huimin,LIU Jing,TANG Caibai,LI Bin,CHEN Weihua,LI Longfei.Research on the relationship between colorectal cancer stem cells CD133(+) and Musashi-1(+) and clinical pathologic factors as well as proteins MGMT,ERCC1 and TS[J].Acta Academiae Medicinae Xuzhou,2010,30(2):104-110. | |
| Authors: | CHENG Huimin LIU Jing TANG Caibai LI Bin CHEN Weihua LI Longfei |
| Institution: | CHENG Huimin1,2,LIU Jing1,TANG Caibai3,LI Bin1,CHEN Weihua4,LI Longfei4 (1.Department of Pathology,Xuzhou Medical College,Xuzhou,Jiangsu 221002,China,2.Department of Pathology,The Third Affiliated Hospital of Xuzhou Medical College,Jiangsu 221004,3.Department of Gastroenterology,The Third Affiliated Hospital of Xuzhou Medical College Xuzhou,4.Department of Pathology,The Second Affiliated Hospital of Xuzhou Medical College,Jiangsu 221006) |
| Abstract: | Objective To investigate the relationship between the colorectal cancer stem cells CD133(+) and Musashi-1(+) and the clinicopathological factors as well as proteins MGMT,ERCC1 and TS.Methods The immunohistochemical method(SP method) was used to detect stem cells CD133,CD138 and Musashi-1 and proteins MGMT,ERCC1 and TS in 42 cases of colorectal cancer tissues.The correlation between the various indicators as well as the relationship between these indicators and clinical pathological factors were analyzed.Res... |
| Keywords: | CD133 Musashi-1 CD138 MGMT ERCC1 TS |
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