序贯治疗对获得性维生素K依赖性凝血因子缺乏症的临床疗效分析

目的分析序贯治疗对获得性维生素K依赖性凝血因子缺乏症（ADVKCF）的临床疗效.方法选择获得性维生素K依赖性凝血因子缺乏症患者44例,随机分为对照组及观察组,分别有21例、23例.分别采用常规治疗及序贯治疗,对治疗后凝血常规、凝血因子、凝血酶原前体蛋白（PIVKA-Ⅱ）进行检测.结果观察组及对照组治疗后PT、INR、APTT、FⅡ、FⅦ、FⅨ、FX较治疗前有改善,差异有统计学意义（P〈0.05）,观察组治疗后PT、INR、APTT、FⅡ、FⅦ、FX较对照组有改善,差异有统计学意义（P〈0.05）.2组治疗后PIVKA-Ⅱ较治疗前有升高,差异有统计学意义（P〈0.05）,观察组患者接受维生素K4治疗后3周T2时较对照组有升高,差异有统计学意义（P〈0.05）.结论大剂量维生素K序贯疗法可有效治疗ADVKCF,对PIVKA-II及凝血常规、凝血因子进行监测有助于明确患者的病情变化.

Analysis of the Clinical Curative Effect of Sequential Treatment on Acquired Vitamin K Dependent Clotting Factor Deficiency

Objective To analyze the clinical curative effect on sequential treatment on acquired vitamin K dependent clotting factor deficiency（ADVKCF）. Methods 44 ADVKCF patients were randomly divided into control group and observation group,there were 21 cases and 23 cases respectively. Patients in control group and observation group were given conventional treatment and sequential treatment, then the coagulation routine,clotting factors,prothrombin precursor protein（PIVKA- Ⅱ） were tested.Results INR,APTT and PT,FⅡ、FⅦ,FⅨ,FX of the observation group and control group after treatment were significantly higher than before treatment（P〈0.05）. INR, APTT and PT,FⅡ,FⅦ,FX of the observation group after treatment were significantly higher than the control group（P〈0.05）. PIVKA-Ⅱ of the two groups after treatment were significantly higher than before treatment（P〈0.05）, the observation group at 3 weeks after vitamin K4 treatment were significantly higher than the control group（P〈0.05）. Conclusion High-dose vitamin K sequential therapy can effectively treat ADVKCF, PIVKA- II and blood coagulation routine,blood coagulation factor monitoring could help to make clear the patient＇s condition changes.