ACE I/D和 CYP11 B2-344 C/T基因多态性与齐齐哈尔汉族人群原发性高血压的关系 |
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引用本文: | 王滨,;姜春玉,;闫晓昆,;赵红晔,;王月飞,;卢长柱,;王玉阁,;赵堃,;肖宇,;孟凡谋. ACE I/D和 CYP11 B2-344 C/T基因多态性与齐齐哈尔汉族人群原发性高血压的关系[J]. 齐齐哈尔医学院学报, 2014, 0(18): 2653-2656 |
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作者姓名: | 王滨, 姜春玉, 闫晓昆, 赵红晔, 王月飞, 卢长柱, 王玉阁, 赵堃, 肖宇, 孟凡谋 |
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作者单位: | [1]齐齐哈尔医学院生理教研室,161006; [2]齐齐哈尔医学院第三附属医院心内科;,161006; [3]黑龙江省齐齐哈尔市第一医院心内科,161006; |
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基金项目: | 黑龙江省教育厅科学技术研究项目(项目编号:12521621) |
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摘 要: | 目的:观察齐齐哈尔地区原发性高血压( EH)患者ACE I/D和CYP11B2-344 C/T基因多态性及其在EH发病中的相互作用。方法 EH患者486例,血压正常者457例。取外周血提取基因组DNA,用PCR-RLFP对ACE I/D和CYP11B2-344 C/T进行基因分型。结果(1)高血压组和血压正常组ACE I/D各种基因型分别为II 0.344/0.326、ID 0.372/0.497、DD 0.284/0.177(P<0.001),D等位基因频率为0.470/0.404(P <0.05);(2)高血压组和血压正常组 CYP11B2-344 C/T 各种基因型分别为 CC 0.136/0.166、CT 0.469/0.438、TT 0.395/0.385(P>0.05),T等位基因频率为0.630/0.615(P>0.05);(3)高血压组DD+CT联合基因型频率高于血压正常组(P<0.01);而高血压组ID+TT联合基因型频率低于血压正常组( P <0.05)。结论 ACE I/D 多态性与齐齐哈尔地区人群的原发性高血压相关, CYP11B2-344 C/T基因多态性与齐齐哈尔地区人群的原发性高血压不相关;但两基因可能存在相互作用。
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关 键 词: | 原发性高血压 血管紧张素转换酶 醛固酮合成酶 基因多态性 |
Relationship between angiotensin converting enzyme and aldosterone synthase gene polymorphisms and essential hypertension in Qiqihar Han population |
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Affiliation: | WANG Bin, et al( Department of Physiology, Qiqihar Medical University, Qiqihar , Heilongjiang 161006, China.) |
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Abstract: | Objective To explore the polymorphism of ACE I/D and CYP11B2-344 C/T and the genetic interaction between ACE and CYP11B2 genes in Qiqhar essential hypetension (EH) Han population.Methods Four hundreds and eighty-six patients with EH and four hundreds and fifty-seven healthy controls were enrolled . Genotyping was performed using PCR-RFLP technique .Results ( 1 ) genotype distributions of ACE I/D ( II 0.344 vs 0.326, ID 0.372 vs 0.497, DD 0.284 vs 0.177,P〈0.001) between EH group and NT group;there was significant differences in D allele frequency of ACE I /D (0.470 vs 0.404, P〈0.05) between two group. (2) genotype distributions of CYP11B2-344 C/T ( CC 0.136 vs 0.166, CT 0.469 vs 0.438, TT 0.395 vs 0.385, P〉0.05) between EH group and NT group;there was not significant differences in T allele frequency of CYP11B2-344 C/T (0.630 vs 0.615, P〉0.05) between two group.(3) The genotype distributions of DD +CT of EH group was significantly higher than that of NT group (P〈0.01), the genotypes distribution of ID +TT of EH group was significantly lower than that of NT group (P〈0.05).Conclusions These observations suggest that ACE I/D polymorphism is associated with essential hypertension in Qiqihar Han population , CYP11B2-344 C/T polymorphism is not associated with essential hypertension in Qiqihar Han population , and there might be mutual effect between the two genes . |
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Keywords: | Essential hypertension ACE CYP11 B2 Gene polymorphisms |
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