| ACE I／D和 CYP11 B2-344 C／T基因多态性与齐齐哈尔汉族人群原发性高血压的关系 |
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| 引用本文： | 王滨,;姜春玉,;闫晓昆,;赵红晔,;王月飞,;卢长柱,;王玉阁,;赵堃,;肖宇,;孟凡谋.ACE I／D和 CYP11 B2-344 C／T基因多态性与齐齐哈尔汉族人群原发性高血压的关系[J].齐齐哈尔医学院学报,2014(18):2653-2656. |
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| 作者姓名： | 王滨 ;姜春玉 ;闫晓昆 ;赵红晔 ;王月飞 ;卢长柱 ;王玉阁 ;赵堃 ;肖宇 ;孟凡谋 |
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| 作者单位： | [1]齐齐哈尔医学院生理教研室,161006; [2]齐齐哈尔医学院第三附属医院心内科;,161006; [3]黑龙江省齐齐哈尔市第一医院心内科,161006; |
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| 基金项目： | 黑龙江省教育厅科学技术研究项目（项目编号：12521621） |
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| 摘 要： | 目的：观察齐齐哈尔地区原发性高血压（ EH）患者ACE I/D和CYP11B2-344 C/T基因多态性及其在EH发病中的相互作用。方法 EH患者486例，血压正常者457例。取外周血提取基因组DNA，用PCR-RLFP对ACE I/D和CYP11B2-344 C/T进行基因分型。结果（1）高血压组和血压正常组ACE I/D各种基因型分别为II 0．344/0．326、ID 0．372/0．497、DD 0．284/0．177（P＜0．001），D等位基因频率为0．470/0．404（P ＜0．05）；（2）高血压组和血压正常组 CYP11B2-344 C/T 各种基因型分别为 CC 0．136/0．166、CT 0．469/0．438、TT 0．395/0．385（P＞0．05），T等位基因频率为0．630/0．615（P＞0．05）；（3）高血压组DD＋CT联合基因型频率高于血压正常组（P＜0．01）；而高血压组ID＋TT联合基因型频率低于血压正常组（ P ＜0．05）。结论 ACE I/D 多态性与齐齐哈尔地区人群的原发性高血压相关， CYP11B2-344 C/T基因多态性与齐齐哈尔地区人群的原发性高血压不相关；但两基因可能存在相互作用。
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| 关 键 词： | 原发性高血压 血管紧张素转换酶 醛固酮合成酶 基因多态性 |
Relationship between angiotensin converting enzyme and aldosterone synthase gene polymorphisms and essential hypertension in Qiqihar Han population |
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| Institution: | WANG Bin, et al( Department of Physiology, Qiqihar Medical University, Qiqihar , Heilongjiang 161006, China.) |
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| Abstract: | Objective To explore the polymorphism of ACE I/D and CYP11B2-344 C/T and the genetic interaction between ACE and CYP11B2 genes in Qiqhar essential hypetension （EH） Han population.Methods Four hundreds and eighty-six patients with EH and four hundreds and fifty-seven healthy controls were enrolled . Genotyping was performed using PCR-RFLP technique .Results （ 1 ） genotype distributions of ACE I/D （ II 0.344 vs 0.326, ID 0.372 vs 0.497, DD 0.284 vs 0.177,P〈0.001） between EH group and NT group;there was significant differences in D allele frequency of ACE I /D （0.470 vs 0.404, P〈0.05） between two group. （2） genotype distributions of CYP11B2-344 C/T （ CC 0.136 vs 0.166, CT 0.469 vs 0.438, TT 0.395 vs 0.385, P〉0.05） between EH group and NT group;there was not significant differences in T allele frequency of CYP11B2-344 C/T （0.630 vs 0.615, P〉0.05） between two group.（3） The genotype distributions of DD ＋CT of EH group was significantly higher than that of NT group （P〈0.01）, the genotypes distribution of ID ＋TT of EH group was significantly lower than that of NT group （P〈0.05）.Conclusions These observations suggest that ACE I/D polymorphism is associated with essential hypertension in Qiqihar Han population , CYP11B2-344 C/T polymorphism is not associated with essential hypertension in Qiqihar Han population , and there might be mutual effect between the two genes . |
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| Keywords: | Essential hypertension ACE CYP11 B2 Gene polymorphisms |
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