10天序贯疗法治疗儿童幽门螺杆菌感染慢性胃炎的疗效分析

目的研究10天序贯疗法与经典三联疗法治疗儿童幽门螺杆菌感染所致慢性胃炎的疗效对比。方法选取60例有慢性胃炎临床症状,胃镜检查为浅表性胃炎,HP快速尿素酶试验检测幽门螺杆菌阳性病例,随机分为两组。治疗组(10天序贯疗法组):前五天给予奥美拉唑、克拉霉素、阿莫西林克拉维酸钾治疗,后五天给予奥美拉唑、克拉霉素及替硝唑治疗。对照组(三联疗法组):给予奥美拉唑、克拉霉素、阿莫西林克拉维酸钾三联治疗,疗程10天。结果治疗组:幽门螺杆菌根除27例(90%),症状改善28例(93.3%),对照组:幽门螺杆菌根除24例(80%),症状改善27例(90%)。Hp根除,两组比较差异有统计学意义(P<0.01),序贯疗法Hp根除率高于三联治疗组。而两组间不良反应率及症状改善率,差异均无统计学意义(P>0.05)。结论 10天序贯疗法幽门螺杆菌根除率优于传统三联疗法,值得在儿童慢性胃炎中应用推广。

10-day sequential therapy in the treatment of chronic gastritis of Helicobacter pylori infection in children clinical analysis

Objective To study curative comparison between 10-day sequential therapy and classical triple therapy in children with chronic gastritis of Helicobacter pylori infection. Methods 60 patients with clinical symptoms of chronic gastritis,superficial gastritis under gastroscope,and being positive cases in HP rapid urease test to detect Helicobacter pylori were randomly divided into two groups.The treatment group(10-day sequential therapy group): first five days given omeprazole,clarithromycin,amoxicillin and clavulanate potassium,followed by five-day omeprazole,clarithromycin and tinidazole.The control group(triple therapy group): given omeprazole,clarithromycin,amoxicillin and clavulanate potassium triple therapy for 10 days. Results in the treatment group,Helicobacter pylori eradication in 27 cases(90%),symptoms improved in 28 cases(93.3%),while the control group,Helicobacter pylori eradication in 24 cases(80%),symptoms improved in 27 cases(90%).In Hp eradication: there was statistical significance between both groups(P<0.01),and Hp eradication rate in sequential therapy is above that in triple therapy group.And no statistical significance in adverse reaction rate and symptom improvement rate between them(P>0.05). Conclusions 10-day sequential therapy for Helicobacter pylori eradication rate is superior to conventional triple therapy in children with chronic gastritis,worthy of application and promotion.