| 4-氯-3-甲氧基-2-甲基吡啶的制备工艺研究 |
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| 引用本文： | 孙新堂,;魏培,;桑林涛,;马寿欣.4-氯-3-甲氧基-2-甲基吡啶的制备工艺研究[J].山东医药工业,2014(9):552-553. |
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| 作者姓名： | 孙新堂 ;魏培 ;桑林涛 ;马寿欣 |
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| 作者单位： | [1]山东畜牧兽医职业学院食品与药品科技系,山东潍坊261061; [2]潍坊市人民医院药剂科,山东潍坊261061 |
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| 摘 要： | 目的对4-氯-3-甲氧基-2-甲基吡啶制备工艺进行优化。方法选择甲苯作为反应溶剂，氧氯化磷稍过量，反应毕直接用氢氧化钠中和，分层萃取，蒸出溶剂即得产品。结果通过对4-氯-3-甲氧基-2-甲基吡啶制备工艺的优化，减少了氧氯化磷的用量，缩短反应时间至2h，降低反应pH值至接近中性。结论本工艺有效地减少了对环境的污染，降低了生产成本，有利于提高经济效益。
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| 关 键 词： | 4-氯-3-甲氧基-2-甲基吡啶 氧氯化磷用量 反应时间 pH值 |
Study on preparation technology of 4 - Chloro - 3 - Methoxy - 2 - Methylpyridine N - Oxide |
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| Institution: | SUN Xin-tang , WEI Pei ,SANG Lin-tao ,MA Shou-xin ( 1. The Food and Drug Department of Science and Technology, Shandong Vocational Animal Science and Veterinary College, Weifang 261061, China ;2. The Pharmacy Department, Weifang City People＇s Hospital, Weifang 261061, China ) |
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| Abstract: | Objective To optimize the preparation technology of 4 - Chloro - 3 - Methoxy - 2 - Methylpyridine N - Oxide＇s. Methods We chose toluene as solvent, oxygen phosphorus chloride was a bit too much, ended the reaction with sodium hydroxide directly ,then extracted hierarchically, evaporated the solvent for the production. Results Through the op- timization of 4- Chloro- 3- Methoxy- 2 -Methylpyridine N- Oxide＇s preparation technology, we reduced the amount of phosphorus oxychloride, shortened the reaction time to 2 h, cured down the reaction pH close to neutral. Conclusion The preparation technology reduced the pollution to the environment and the production cost effectively, and improves the eco- nnmic benefits. |
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| Keywords: | 4 - Chloro - 3 - Methoxy - 2 - Methylpyridine N - Oxide Amount of phosphorus oxychloride Reactiontime pH |
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