| 窒息胎鼠血浆组织型纤溶酶原激活剂及其抑制物的变化 |
| |
| 引用本文： | 张更,徐剑文,王玮,康仲涵.窒息胎鼠血浆组织型纤溶酶原激活剂及其抑制物的变化[J].福建医科大学学报,2003,37(1):51-52. |
| |
| 作者姓名： | 张更 徐剑文 王玮 康仲涵 |
| |
| 作者单位： | 福建医科大学,人体解剖学与组织胚胎学系,福州,350004 |
| |
| 基金项目： | 福建省科技厅三项费资助项目 ( K2 0 0 45 ) |
| |
| 摘 要： | 目的 探讨窒息对胎鼠血浆中组织型纤溶酶原激活剂（t－PA）及其抑制物（PAI）活性的影响。方法 通过“延迟剖宫产术”致胎鼠宫内窘迫，实验分5个组：空白对照组、窒息15min组、窒息30min组、窒息15min复氧30min组、窒息30min组。分别测试各组血浆t－PA和PAI的活性。结果 窒息后t－PA活性升高（P＜0．05），窒息后复氧PAI活性升高（P＜0．01）。结论 窒息可致血浆纤溶酶活性改变。
|
| 关 键 词： | 组织型纤维酶原激活物 纤溶酶原激活剂抑制物 窒息 血浆 小鼠 |
| 文章编号： | 1000-2235(2003)01-0051-02 |
| 修稿时间： | 2002年12月6日 |
Changes of Tissue-type Plasminogen Activator and Plasminogen Activator Inhibitor Activity in Plasma of Asphyxial Fetal Mice Embryo |
| |
| ZHANG Geng,XU Jian\|wen,WANG Wei,KANG Zhong\|han.Changes of Tissue-type Plasminogen Activator and Plasminogen Activator Inhibitor Activity in Plasma of Asphyxial Fetal Mice Embryo[J].Journal of Fujian Medical University,2003,37(1):51-52. |
| |
| Authors: | ZHANG Geng XU Jian\|wen WANG Wei KANG Zhong\|han |
| |
| Abstract: | Objective\ To observe the changes of the activity of tissue\|type plasminogen activator(t\|PA) and plasminogen activator inhibitor(PAI) in blood plasma of fetal mice after asphyxia.\ Methods\ Asphyxia was induced in mouse embryo by performing a "delayed cesarean section".\ The experiment was designed to detect the activity of t\|PA and PAI in control group and 4 asphycxia groups.\ Results\ The activity of t\|PA increased after asphyxia(P<0 05) and the activity of PAI increased after reoxygenation(P<0 01).\ Conclusion\ Asphyxia led to the changes of fibrinolytic activity in blood plasma. |
| |
| Keywords: | tissue\|type plasminogen activator plasminogen activator inhibitor asphyxia blood plasma mice |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
