生存素在胃癌组织的表达及临床意义

目的　探讨生存素在胃癌组织中的表达及其临床意义。　方法　应用免疫组织化学 SP法检测 1 0 5例胃癌组织中生存素的表达 ,分析生存素表达与临床病理学特征及预后的关系。　结果　胃癌组织中生存素表达的阳性率为4 7.6 %。生存素的表达与肿瘤浸润深度、淋巴结转移、TNM分期呈正相关性 (r分别为 :0 .2 83,0 .2 30和 0 .2 34,P<0 .0 5 ) ,与患者年龄、性别、肿瘤部位、Borrm ann分型及组织分化未见相关。生存素表达阳性者的 5年生存率 (30 .0 % )明显低于表达阴性者 (5 6 .4 % ,P=0 .0 0 7)。Cox回归模型显示 ,生存素表达与胃癌预后密切相关 (P<0 .0 5 ) ,是影响胃癌预后的独立因素。　结论　生存素在胃癌组织中高表达 ,且与肿瘤浸润深度、淋巴结转移及临床分期密切相关 ,是影响胃癌预后的重要分子指标

Expression and Clinical Significance of Survivin in Gastric Carcinoma

Objective To investigate the expression and clinical significance of survivin in gastric carcinoma. Methods The expression of survivin in gastric carcinoma was examined immunohistochemically using SP staining method. The relationship between survivin expression and the clinicopathologic parameters, prognosis was analyzed. Results Survivin was expressed in 47 6% of gastric carcinoma. The positive expression of survivin was significantly related to the infiltration, lymph node metastasis and TNM stage(P<0 05), but had no correlation with the age, sex, tumor location, Borrmann's type and histological grade(P>0 05). The 5-year survival rate was significantly lower with survivin positively staining(30 0%) than survivin negative(56 4%, P=0 007). Cox regression indicated survivin was an independent prognostic marker of gastric carcinoma. Conclusion Survivin was overexpressed in gastric carcinoma. Expression of survivin had a significant relation with the invasion depth, lymph node metastasis, TNM stage and poor prognostis. Survivin is an important prognostic indicator of gastric carcinoma.;