| 完全梗阻性黄疸持续时间对大鼠肝切除术后肝再生的影响 |
| |
| 引用本文： | 刘景丰,张清华,曾永毅,黄新辉,刘建煌.完全梗阻性黄疸持续时间对大鼠肝切除术后肝再生的影响[J].福建医科大学学报,2009,43(2):114-117. |
| |
| 作者姓名： | 刘景丰 张清华 曾永毅 黄新辉 刘建煌 |
| |
| 作者单位： | 福建医科大学附属第一医院肝病中心,福州350005 |
| |
| 基金项目： | 福建省科技厅青年人才项目(2007F301030129) |
| |
| 摘 要： | 目的探讨术前完全梗阻性黄疸的持续时间对大鼠肝切除术后肝再生的影响。方法建立完全梗阻性黄疸大鼠模型，测定梗阻不同时相的胆红素水平；选取梗阻0，1，3，7d分为4组。即正常肝切除组（A组）、梗阻1d肝切除组（B组）、梗阻3d肝切除组（C组）及梗阻7d肝切除组（D组），观察肝切除（肝切除量约70％）术后各组大鼠死亡率，检测肝切除术后0，12，24，48，72，168h的肝功能指标，免疫组织化学检测残肝组织PCNA标记指数，RT-PCR法检测肝组织HGF基因的表达，检测术后7d残肝质量／体质量的比值。结果B组在肝切除术后死亡率、肝功能恢复、PCNA标记指数、HGFmRNA表达及肝质量／体质量的比值等方面均优C组及D组，差别均有统计学意义（P〈0．05）。结论术前高胆红素血症可明显抑制大鼠肝切除术后的肝再生；术前梗阻时间短、胆红索处于较低水平，扩大肝叶切除术才可能相对安全地进行。
|
| 关 键 词： | 黄疸 阻塞性 胆管肿瘤 肝切除 肝再生 疾病模型 动物 |
Effect of Obstructive Jaundice of Different Degrees on the Liver Regeneration in Rats of Post-hepatectomy |
| |
| LIU Jingfeng,ZHANG Qinghua,ZENG Yongyi,HUANG Xinhui,LIU Jianhuang Center of Hepatic Diseases,The Affiliated First Hospital,Fujian Medical University,Fuzhou ,China.Effect of Obstructive Jaundice of Different Degrees on the Liver Regeneration in Rats of Post-hepatectomy[J].Journal of Fujian Medical University,2009,43(2):114-117. |
| |
| Authors: | LIU Jingfeng ZHANG Qinghua ZENG Yongyi HUANG Xinhui LIU Jianhuang Center of Hepatic Diseases The Affiliated First Hospital Fujian Medical University Fuzhou China |
| |
| Institution: | LIU Jingfeng,ZHANG Qinghua,ZENG Yongyi,HUANG Xinhui,LIU Jianhuang Center of Hepatic Diseases,The Affiliated First Hospital,Fujian Medical University,Fuzhou 350005,China |
| |
| Abstract: | Objective To explore the effect of obstructive jaundice of different degrees on the liver regeneration in rats of post-hepatectomy. Methods Rat models with obstructive jaundice were set up and used for evaluating bilirubin in different periods. A group,B group,C group and D group were established respectively in accordance with the level of bilirubin at 0,1,3 and 7 days. The rats then received hepatectomy(about 70% of total liver). Mortality was thus followed. The observance of liver function was conducted ... |
| |
| Keywords: | jaundice obstructive bile duct neoplasms hepatectomy liver regeneration disease models animal |
| 本文献已被 CNKI 维普 等数据库收录！ |
