GATA3在不同分子分型乳腺癌组织中的表达及与预后关系

目的研究GATA结合蛋白3(GATA3)在乳腺癌组织中的表达与临床病理指标的关系,探讨 GATA3在乳腺癌不同亚型中的表达及预后意义。方法回顾性分析209例乳腺癌患者的临床病理资料。采用免疫组织化学法检测GATA3、雌激素受体(ER)、孕激素受体(PR)、人表皮生长因子受体2(Her-2)、雄激素受体(AR)、Ki-67增殖指数的表达,采用χ²检验分析GATA3在乳腺癌不同亚型中的表达,采用Kaplan-Meier法进行生存资料分析。结果GATA3的低表达与肿瘤低分化、淋巴结转移、TNM分期等指标相关(P<0.05)。乳腺癌组织中GATA3表达与ER,PR,AR表达呈正相关,与Ki-67增殖指数呈负相关(P<0.05)。GATA3在三阴性乳腺癌中表达率(17.5%)低于非三阴性乳腺癌中表达率(71.0%)(P<0.05); GATA3在Luminal A型、Luminal B型、Her-2过表达型、三阴性乳腺癌组织中表达率分别为89.8%,79.1%,43.4%及17.5%(P<0.05)。在 Luminal型乳腺癌不同临床分期中,GATA3(+)组患者的无病生存期较GATA3(-)患者更长(P<0.05)。结论 GATA3表达与乳腺癌分子分型有关,且参与乳腺癌的发展、转移,可作为判断预后的辅助指标。

The Expression of GATA3 in Breast Cancer Tissues with Different Molecular Types and its Correlationship with Prognosis

ObjectiveTo investigate the correlationship between the expression of GATA binding protein 3(GATA3)and clinicopathological parameters in breast neoplasms, and to further explore the expression of GATA3 in breast cancer tissues with different molecular types and its prognostic significance.MethodsThe clinicopathological data of 209 patients with breast cancer were analyzed retrospectively.The expression of GATA3, ER, PR, Her-2, AR and Ki-67 were evaluated by immunohistochemical staining assays.The expression of GATA3 in different molecular types of breast neoplasms were then assessed using the Chi-square test.The Kaplan-Meier method was used for the analysis of survival. ResultsLow expression of GATA3 in breast cancer tissues was associated with low tumor differentiation, lymph node involvement, late TNM staging(P<0.05).There was a positive correlation between GATA3 expression and ER, PR and AR expression in breast cancer tissues.There was a negative correlation with Ki-67 proliferation index, and the differences were statistically significant(P<0.05).The expression rate of GATA3 in triple negative breast cancer(17.5%)was lower than that in non-triple negative breast cancer(71.0%)(P<0.05).The expression rates of GATA3 in Luminal A, Luminal B, Her-2 overexpression and triple negative breast cancer tissues were 89.8%, 79.1%, 43.4% and 17.5%, respectively.In different clinical stages of Luminal breast cancer, the disease-free survival time of patients in GATA3(+)group was significantly longer than that in GATA3(-)group(all P<0.05).ConclusionThe expression of GATA3 is related to the molecular typing of breast neoplasms and involves in the development and metastasis of breast cancer, which can be used as an auxiliary index to predict the prognosis.