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| 广西南北两地人群肝组织黄曲霉毒素B1暴露的对比 | |
| 引用本文： | 苏卡,彭涛,李裕波,窦东伟,苏浩,李佳荃,秦雪,覃晓,黎乐群,刘志明. 广西南北两地人群肝组织黄曲霉毒素B1暴露的对比[J]. 广西医科大学学报, 2011, 28(2): 165-168 |
| 作者姓名： | 苏卡 彭涛 李裕波 窦东伟 苏浩 李佳荃 秦雪 覃晓 黎乐群 刘志明 |
| 作者单位： | 1. 广西医科大学第一附属医院胃肠腺体外科,南宁,530021 2. 广西医科大学第一附属医院肝胆外科,南宁,530021 3. 广西医科大学第一附属医院检验科,南宁,530021 |
| 基金项目： | 国家自然科学基金资助项目 |
| 摘 要： | 目的:通过比较广西北回归线两侧的南宁地区和桂林地区人群肝组织黄曲霉毒素B1(Aflatoxin B1,AFB1)的暴露水平,探讨AFB1暴露与原发性肝细胞癌(Hepatocellular carcinoma,HCC)发生的关系.方法:应用免疫组化法检测南宁和桂林地区共165例HCC患者和95例正常肝组织中AFB1-DN... |
| 关 键 词： | 黄曲霉毒素B1 加合物 肝细胞癌 免疫组织化学 |
COMPARISON OF AFLATOXIN B1 EXPOSURE IN LIVER TISSUES BETWEEN GUANGXI NORTHERN AND SOUTHERN POPULATION |
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| Su Ka,Peng Tao,Li Yubo,Dou Dongwei,Su Hao,Li Jiaquan,Qin Xue,Qin Xiao,Li Lequn,Liu Zhiming. COMPARISON OF AFLATOXIN B1 EXPOSURE IN LIVER TISSUES BETWEEN GUANGXI NORTHERN AND SOUTHERN POPULATION[J]. Journal of Guangxi Medical University, 2011, 28(2): 165-168 | |
| Authors: | Su Ka Peng Tao Li Yubo Dou Dongwei Su Hao Li Jiaquan Qin Xue Qin Xiao Li Lequn Liu Zhiming |
| Affiliation: | .(Department of Gastrointestinal Surgery,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China) |
| Abstract: | Objective：To explore the association between aflatoxin B1（AFB1） exposure and the development of hepatocelluar carcinoma（HCC）.Methods：Immunohistochemistry method was used to detect the levels of AFB1-DNA adducts.A total of 260 cases of HCC and non-HCC liver tissues were categorized into 4 groups according to their residency,HCC group（n=79） and controls（n=58） from Nanning area,HCC group（n=86） and controls（n=37） from Guilin area.Results：The AFB1-DNA adduct levels from Nanning area was significantly higher than those from Guilin area（χ2=31.042,P0.001）.The AFB1-DNA adduct levels of HCC and control groups from Nanning area were different（χ2=21.484,P0.001）,but there was no difference in AFB1-DNA adduct levels between HCC and control groups from Guilin area（χ2=0.318,P=0.573）.Conclusion：There is a regional difference in AFB1 exposure in Guangxi,the AFB1-DNA adduct levels from Nanning area are much higher than those from Guangxi area.The AFB1 exposure is a risk factor for the hepatocarcinigenesis of HCC in Nanning area. |
| Keywords: | aflatoxin B1 adduct hepatocellular carcinoma immunohistochemistry |
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