糖尿病性眼病的组织结构变化与防治的研究初步报告

本文系统观察糖尿病鼠形成糖尿病性眼病的组织结构变化,共76例,非胰岛细胞移植组有67%出现白内障,并在出现白内障前,虹膜、睫状体和视网膜微血管增多和扩大,虹膜和睫状体上皮细胞退变.胰岛细胞移植组未见1例白内障,提示糖尿病性白内障的形成,可能由于血糖过高,葡萄糖通过山梨醇旁路代谢增多引起外;还可能由于糖代谢紊乱造成眼的微血管变化,睫状上皮细胞退变,引起眼房水产生和循环不良所致.胰岛移植能较好纠正糖代谢紊乱,防止糖尿病性眼病是可能的.

A PRELIMIARY REFORT CONCERNING THE STRUCTURAL CHANGES AND PREVENTION OF DIABETIC OCULOPATHY

Cultured Pancreatic islet cells were transplanted to rats with experimental diabetes mellitus.Without giving any insulin the blood sugar level dropped down 54.4-58.3% (P<0.01).The blood sugar level in the non-trans-planted group maintained within 394.05-411.9mg/dl.There was a serious loss of fluids in the rats.Cataracts appeared in altogether 25rats (67%).The capillaries of the conjunctiva bulbi, iris, cilliary body and retina were increased and enlarged, and there was thickening of the basal menbrane.The lens fibers arrange ment was in disoder and degeneration was present.The cilliary body was swollen.The structural changes of the cilliary epithelium included vucuolar formation, degeneration and pyknosis.In the transplantation group cataracts did not appear even after three months.We consider that transplantation of pancreatic islet cells has an effect in lowering blood sugar level and in preventing diabetic oculopathy.