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寻常型天疱疮与大泡性类天疱疮皮损角质形成细胞Fas和Fas-L表达的研究
引用本文:郑文军,林有坤,罗虹,潘尚领,梁伶,严煜林,曹存巍.寻常型天疱疮与大泡性类天疱疮皮损角质形成细胞Fas和Fas-L表达的研究[J].广西医科大学学报,2004,21(4):484-485.
作者姓名:郑文军  林有坤  罗虹  潘尚领  梁伶  严煜林  曹存巍
作者单位:1. 广西医科大学第一附属医院皮肤科,南宁,530021
2. 广西医科大学病理生理学教研室
基金项目:广西卫生厅资助项目 ( 9911)
摘    要:目的 :探讨 Fas和 Fas- L在寻常型天疱疮 (PV)和大泡性类天疱疮 (BP)皮损发生发展中的作用。方法 :采用免疫组化方法研究两病患者皮损 Fas和 Fas- L的表达情况。结果 :1角质形成细胞 Fas/Fas- L表达的部位 :PV,疱内分离的及疱周围的棘层细胞 ;BP,水泡上方及附近的棘层细胞 ;2寻常性天疱疮、大泡性类天疱疮表皮细胞 Fas/Fas- L表达都明显高于正常对照组(均 P <0 .0 1)。结论 :角质形成细胞 Fas/Fas- L表达异常与 PV和 BP皮损的发生可能有密切联系

关 键 词:寻常型天疱疮  大泡性类天疱疮  角质形成细胞  Fas  Fas—L  表达
修稿时间:2004年4月13日

THE STUDY OF FAS AND FAS-L EXPRESSION IN KERATINOCYTES OF PEMPHIGUS VULGARIS AND BULLOUS PEMPHIGOID SKIN LESIONS
Zheng Wenjun,Lin Youkun,Luo Hong,et al..THE STUDY OF FAS AND FAS-L EXPRESSION IN KERATINOCYTES OF PEMPHIGUS VULGARIS AND BULLOUS PEMPHIGOID SKIN LESIONS[J].Journal of Guangxi Medical University,2004,21(4):484-485.
Authors:Zheng Wenjun  Lin Youkun  Luo Hong  
Abstract:Objective:To investigate the possible roles of Fas and Fas-L in the mechanisms of Pemphigus Vulgaris(PV) and Bullous Pemphigoid(BP).Methods:Immunohistochemical method was used to determine the expression of Fas and Fas-L of patients with PV and BP and the expression was compared with that of controls respectively.Result:1)The expressing sites of Fas/ Fas-L of Keratinocytes:PV,found in spinous layer cells detached in or surrounding the blisters;BP,found in spinous layer cells attached on the blisters or nearby. 2) The expressions of Fas/ Fas-L in PV and BP patients were significantly higher than that of controls(P<0.01,respectively).Conclusion:The abnormal expression of Fas/Fas-L of Keratinocytes may be involved in the skin injury in PV and BP patients.
Keywords:pemphigus vulgaris  bullous pemphigoid  keratinocytes  Fas  Fas-L
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