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| 肿节风浸膏溶液对鼻咽癌细胞系CNE-2的放射增敏作用 | |
| 引用本文： | 王仁生,黄国军,韦波,蒋伟哲,吴芳,刘文其.肿节风浸膏溶液对鼻咽癌细胞系CNE-2的放射增敏作用[J].广西医科大学学报,2009,26(2):208-210. |
| 作者姓名： | 王仁生 黄国军 韦波 蒋伟哲 吴芳 刘文其 |
| 作者单位： | 1. 广西医科大学第一附属医院放疗科,南宁,530021 2. 广西医科大学流行病学教研室 3. 广西医科大学药学院 |
| 摘 要： | 目的：探讨肿节风浸膏对鼻咽癌细胞系CNE-2的细胞毒性作用以及对放射敏感性的影响。方法：应用克隆形成方法，观察不同浓度的肿节风浸膏对CNE-2的细胞杀灭效应，求得IC50，选择合适浓度的肿节风浸膏配合照射和单纯照射对细胞的杀伤作用，计算细胞存活率，用多靶单击数学模型进行曲线拟合作图。结果：与照射配合的肿节风浸膏的合适浓度为10mg／L。单纯照射组D0值为3．096Gy，照射加肿节风浸膏组D0值为2．441Gy，放射增敏比（SER）为1．268（3．096／2．441）。结论：肿节风浸膏具有一定的放射增敏作用。 |
| 关 键 词： | 肿节风浸膏溶液 鼻咽癌细胞系 放射增敏 |
THE SENSITIZING ENHANCEMENT EFFECT OF SARCANDRA GLABRA ON THE IRRADI-ATION TO NASOPHARYNGEAL CARCINOMA CELL CNE-2 |
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| Institution: | Wang Rensheng, Huang Guojun,Wei Bo, et al. (Department of radiotherapy, the first affiliated hospital of Guangxi Medical University,Nanning 530021 China) |
| Abstract: | Objective： To study the radiation sensitizing enhancement effect of Sarcandra glabra on nasopharyhgeal carcinoma cell line CNE-2 in vitro. Methods：The nasopharyngeal carcinoma cell line CNE-2 was treated in vitro with different doses of radiation alone and radiation after Sarcandra glabra. Colony forming assay was used for survival fraction analysis. Single-hit multitarget model was used to plot survival curve. Results：The value of Do of CNE-2 cells received radiation treatment alone was 3. 096 Gy. That of CNE-2 cells received radiation plus Sarcandra glabra was 2. 441 Gy. The sensitization enhancement ratio（SER） was 1. 268. Conclusion：Sarcandra glabra has been shown a radiosensitizing effect on nasopharyngeal carcinoma cells in vitro. |
| Keywords: | sarcandra glabra carcinoma cell line radiosensitization |
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