艾司西酞普兰与帕罗西汀治疗惊恐障碍对照研究

目的:研究艾司西酞普兰和帕罗西汀治疗惊恐障碍的有效性和安全性。方法:55例惊恐障碍患者随机分入艾司西酞普兰组与帕罗西汀组治疗10周,在治疗前和治疗期间隔周测定惊恐症状评定量表(PASS)、汉密尔顿焦虑量表(HAMA)及每周发作次数,以治疗中出现的症状量表(TESS)评定不良反应。结果:艾司西酞普兰组有效率为96.2%,帕罗西汀组为92.3%,二药相近。两组患者在治疗10周PASS、HAMA的减分率差异无显著性。艾司西酞普兰组的起效时间快于帕罗西汀组,差异具有显著性(P<0.01)。两组患者均有良好的耐受性。结论:艾司西酞普兰是一种起效快、疗效好、安全性高的治疗惊恐障碍的药物。

Study of escitalopram and paroxetine in treatment of panic disorder

Objective:To evaluate the efficacy and safety of escitalopram and paroxetine in the treatment of patients with panic disorder.Methods:Fifty-five patients with panic disorder were randomly assigned to escitalopram group or sertraline group for 10 weeks.The panic symptom scale(PASS),Hamilton anxiety scale(HAMA) were used to evaluate the efficacy,and the treatment emergent symptom scale(TESS) were used to evaluate the side effects.Results: After 10 weeks treatment,the mean scores of PASS,HAMA reduced in both groups.The rates of efficacy of escitalopram and paroxetine were 96.2% and 92.3% respectively,and there were no statistically significant differences in the efficacy between two groups.But it took effect more quickly in escitalopram group than in paroxetine group(P<0.01).Patients of both groups had good tolerance.Conclusions: Escitalopram is an effective and well-tolerated drug in the treatment of panic disorder,and takes effect quickly.