五种非典型抗精神病药物对16岁以下精神分裂症患者肝功能指标及血液学指标的影响

目的:探讨五种非典型抗精神病药物对16岁以下精神分裂症患者肝功能及血液学的影响。方法:对183例16岁以下精神分裂症患者根据其治疗情况分为5组,分别为利培酮组(53人),喹硫平组(36人),奥氮平组(47人),阿立哌唑组(25人),帕利哌酮组(22人),分别给予利培酮(2.5～4.5 mg/日)、喹硫平(400～800 mg/日)、奥氮平(5～20 mg/日)、阿立哌唑(5～20 mg/日)及帕利哌酮(3～9 mg/日)治疗,疗程12周。每隔4周查患者肝功能及血液学指标,观察检查结果是否存在异常,并进行处理。结果:5组方法治疗后均有患者肝功能及血液学检查有异常。阿立哌唑组及帕利哌酮组出现肝功能及血液学异常的几率最低,阿立哌唑组肝功能异常发生率为8.00%,血液学异常发生率为4.00%,帕利哌酮组肝功能异常发生率为9.09%,血液学异常发生率为4.55%,两组间差异无显著性(P﹥0.05)。喹硫平组及奥氮平组对肝功能的影响较小,喹硫平组发生率为11.11%,奥氮平组发生率为10.64%,对血液学的影响稍大,分别为8.33%、8.51%,两组间差异无显著性(P﹥0.05)。对肝功能的影响最大的是利培酮组,为26.42%,与其他四组相比差异均有显著性(P﹤0.05),但对血液学的影响较小,为5.66%。结论:阿立哌唑及帕利哌酮对于16岁以下精神分裂症患者的治疗有明确的安全性。

Effects of 5 kinds of atypical antipsychotic drugs in patients with schizophrenia under the age of 16 liver function indicators and hematological

Objective:To discuss of five kinds of atypical antipsychotic drugs on schizophrenic patients under the age of 16 liver function and hematological effects.Methods:183 patients under the age of 16,according to their treatment of patients with schizophrenia were divided into five groups,namely,the 1st group risperidone group(53 persons),the 2ed groups quetiapine group(36 persons),the 3rd groups olanzapine group(47 persons),the 4th groups of aripiprazole group(25 persons),the 5th groups paliperidone group(22 persons),were given risperidone(2.5 mg~4.5 mg/day),quetiapine(400 mg~800 mg/day),olanzapine(5 mg~20 mg/day),aripiprazole(5 mg~20 mg/day),or paliperidone(3 mg~9 mg/day) treatment for 12 weeks.Check every 4 weeks in patients with liver function and hematological index,to observe the existence of abnormal test results,and processing.Results: 5 groups’ method after treatment both in patients with liver function and hematology examination abnormalities.The aripiprazole group and the paliperidone group of liver function and hematological abnormalities likely the lowest the aripiprazole group of abnormal liver function,incidence of 8.00%,hematology abnormal incidence of 4.00%,the paliperidone group of abnormal liver function,incidence of 9.09%,hematology abnormal incidence of 4.55% between the two groups difference was not statistically significant(P﹥0.05).The quetiapine group and the olanzapine group,on liver function in small,the quetiapine group incidence of 11.11%,the olanzapine group incidence of 10.64%,for hematology impact of larger,Respectively,8.33%,8.51%,no significant difference between the two groups(P﹥0.05).The greatest impact on liver function are the risperidone group,for 26.42%,compared with the other four differences were statistically significant(P﹤0.05),but little effect on hematology,to 5.66%.Conclusions: Aripiprazole and Paliperidone 16 years of age for the treatment of patients with schizophrenia have a clear security.