卡贝缩宫素和缩宫素治疗剖宫产高危产妇的效果比较

目的:比较卡贝缩宫素和缩宫素治疗剖宫产高危产妇的效果。方法:选取122例剖宫产高危产妇为研究对象,按照随机数字表法分为观察组与对照组各61例。两组均行剖宫产手术,胎儿娩出后,对照组给予缩宫素治疗,观察组给予卡贝缩宫素治疗,比较两组术中、产后2、24 h出血量,产后加用前列素氨丁三醇率,凝血功能指标纤维蛋白原(FIB)、D-二聚体(D-D)、凝血酶原时间(PT)、部分凝血活酶时间(APTT)]水平,心率,血压,血红蛋白水平和不良反应发生率。结果:观察组术中、产后2、24 h出血量均低于对照组,差异有统计学意义(P<0.05);观察组加用卡前列素氨丁三醇率为4.92%(3/61),明显低于对照组的16.39%(10/61),差异有统计学意义(P<0.05);术后,两组FIB、D-D水平均高于术前,且观察组高于对照组,两组PT、APTT均短于术前,且观察组短于对照组,差异有统计学意义(P<0.05);术后,两组血红蛋白水平均低于术前,但观察组高于对照组,差异有统计学意义(P<0.05);手术前后,两组心率、血压和不良反应发生率比较,差异均无统计学意义(P>0.05)。结论:卡贝缩宫素治疗剖宫产高危产妇可减少出血量和加用卡前列素氨丁三醇率,提高其术后血红蛋白水平,以及改善凝血功能指标,效果优于缩宫素。

Comparison of effects of Carbetocin and Oxytocin in treatment of high-risk pregnant women undergoing cesarean section

Objective:To compare effects of Carbetocin and Oxytocin in treatment of high-risk pregnant women undergoing cesarean section.Methods:122 high-risk pregnant women undergoing cesarean section were selected as the research objects,and were divided into observation group and control group according to the random number table method,61 cases in each.Both groups underwent cesarean section.After the delivery,the control group was given Oxytocin,while the observation group was given Carbetocin.The bleeding amounts during the surgery as well as 2 and 24 hours after delivery,the Carprostol tromethamine rate after delivery,the coagulation function index levelsplasma fibrinogen(FIB),D-dimer(DD),prothrombin time(PT),partial thromboplastin time(APTT)],the levels of heart rate,blood pressure and hemoglobin,and the incidence of adverse reactions were compared between the two groups.Results:The bleeding amounts during the surgery as well as 2 and 24 hours after delivery in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The Carprostol tromethamine rate in the observation group was 4.92%(3/61),which was significantly lower than 16.39%(10/61)in the control group,and the difference was statistically significant(P<0.05).After the surgery,the levels of FIB and DD in the two groups were higher than those before the surgery,and those of the observation group were higher than the those of the control group;the levels of PT and APTT in the two groups were shorter than those before the surgery,and those of the observation group were shorter than those of the control group;and the differences were statistically significant(P<0.05).After operation,the hemoglobin levels in the two groups were lower than those before the surgery,but that of the observation group was higher than that of the control group;and the differences were statistically significant(P<0.05).Before and after the surgery,there were no significant differences in heart rate,blood pressure and incidence of adverse reactions between the two groups(P>0.05).Conclusions:Carbetocin in the treatment of the highrisk pregnant women undergoing cesarean section can reduce the bleeding amount and the Carprostol tromethamine rate,increase the postoperative hemoglobin level,and improve the levels of coagulation function indicators.Moreover,it is superior to Oxytocin.