血浆甲状腺素水平与老年痴呆发病的相关性研究

目的:分析甲状腺激素(Thyroid hormones,TH)与老年痴呆(AD)发病的相关性。方法:对住院治疗的老年痴呆患者和同期来体检的健康老年人采集血样,检测血浆HCY含量,进行非条件Logistie回归分析,对TH是否为老年痴呆的独立危险因素进行判断。结果:AD患者血浆Th水平明显低于正常同龄老年人(t=4.980,P<0.001);Logistic回归分析显示,低TH是AD发生的重要危险因素(OR=4.792,P<0.01)。结论:老年痴呆患者TH含量明显偏低,是该病发生的重要危险因素之一,须得到临床医师的重视。

Correlations among thyroid hormone levels and development of senile dementia

Objective：To analyze correlation between thyroid hormone （Th） and development of dementia （AD）. Methods：In Alzheimer＇s disease patients and healthy elderly for physical examination in the same period, blood samples were collected. Plasma HCY levels were detected, and investigated with unconditional Logistic regression analysis in order to determine whether thyroid hor-mone was an independent risk factor for dementia. Results： The plasma thyroid hormone levels in the patients with AD were significant-ly lower than normal old people （t=4. 980, P〈0. 001）. Logistic regression analysis showed that low thyroid hormone was the important risk factor for AD development （OR=4. 792, P〈0. 01）. Conclusions： The thyroid hormone content is significantly lower in the pa-tients with dementia, and is the important risk factor for disease development. Therefore, the clinicians should pay more attention to it.