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TPS、CA-153和CEA联合检测对乳腺癌的诊断价值
引用本文:郑航,罗荣城.TPS、CA-153和CEA联合检测对乳腺癌的诊断价值[J].第一军医大学学报,2005,25(10):1293-1294,1298.
作者姓名:郑航  罗荣城
作者单位:南方医科大学南方医院肿瘤科,广东广州510515
摘    要:目的探讨组织多肽特异性抗原(TPS)、癌相关糖蛋白抗原(CA153)和癌胚抗原(CEA)三项标志物联合检测对乳腺癌的诊断价值.方法乳腺癌患者90例,乳腺良性疾病40例,健康对照组30例,应用酶联免疫吸附试验(ELISA)检测TPS、CA153和CEA三项标志物.结果乳腺癌组三项指标均明显高于健康对照组(P<0.01).TPS对乳腺癌诊断的敏感性为87.7%,特异性为90.0%;CA153敏感性为55.6%,特异性为93.3%;CEA敏感性为45.8%,特异性为96.7%.三项联合则敏感性为100%.结论TPS、CA153和CEA对乳腺癌诊断有一定价值,三者联合检测有明显的互补性,可明显提高乳腺癌诊断的敏感性.

关 键 词:乳腺肿瘤  肿瘤标志物  组织多肽特异性抗原  癌相关糖蛋白抗原  癌胚抗原
文章编号:1000-2588(2005)10-1293-02
收稿时间:2005-01-10
修稿时间:2005-01-10

Diagnostic value of combined detection of TPS, CA153 and CEA in breast cancer
Zheng Hang;Luo RongCheng.Diagnostic value of combined detection of TPS, CA153 and CEA in breast cancer[J].Journal of First Military Medical University,2005,25(10):1293-1294,1298.
Authors:Zheng Hang;Luo RongCheng
Institution:Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Abstract:OBJECTIVE: To study the diagnostic value of combined detection of the 3 tumor markers, namely tissue polypeptide specific antigen (TPS), cancer antigen 153 (CA153), and carcino embryonic antigen (CEA), in patients with breast cancer. METHODS: The serum levels of TPS, CA153 and CEA were determined by enzyme-linked immumosorbent assay in 90 patients with breast cancer and 30 healthy adults. RESULTS: The serum levels of 3 tumor markers in breast cancer patients were significantly higher than those in the control group (P<0.01). The sensitivity of TPS to breast cancer was 87.7% with specificity of 90.0%. The sensitivity and specificity of CA153 to breast cancer was 55.6% and 93.3%, and those of CEA was 45.8% and 96.7%, respectively. The sensitivity of the 3 tumor markers in combination was 100% in breast cancer diagnosis. CONCLUSION: TPS, CA153 and CEA have diagnostic value in breast cancer and possess obvious complementarity, and their combined detection can significantly improve the sensitivity of breast cancer diagnosis.
Keywords:breast neoplasm  tumor markers  tissue polypeptide specific antigens  cancer antigen 153  carcino embryonic antigen
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