定量测定血清心肌肌钙蛋白Ⅰ、肌红蛋白在急性心肌梗死诊治中的应用 |
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摘 要: |
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关 键 词: | 肌钙蛋白Ⅰ 肌红蛋白 肌酸激酶MB 急性心肌梗死 |
Quantitative analysis of serum troponin I and myoglobin in patients with acute myocardial infarction] |
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Authors: | Hong-guang Xiao Ze-hong Huang Han-Xin Liu Yong-ping Lin |
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Institution: | Department of Clinical Laboratory, Guangzhou Medical College, Guangzhou 510120, China. xiaohongguang610904@yahoo.com.cn |
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Abstract: | OBJECTIVE: To investigate the clinical implications of cardiac troponin I (cTnI), myoglobin (Mb), creatine kinase (CK) and creatine kinase isoenzyme (CK-MB) in patients with acute myocardial infarction (AMI). METHODS: The serum concentrations of cTnI and Mb were determined in 50 patients with AMI 2 to 4 h after chest pain onset and compared with those measured in 50 age-matched healthy subjects. RESULTS: The serum levels of cTnI, CK-MB and CK in patients with AMI were significantly higher than those in the control group. Mb levels in AMI group were above the normal range. Mb, CK-MB, CK and cTnI reached the peak levels at 8+/-2.2, 18.1+/-3.2, 19.4+/-4.1 and 18.6+/-2.9 h after the onset, respectively, and their levels increased with the aggravation of AMI and were reduced to the normal levels with the amelioration of the disease. All the 4 indices were normal in the control group. CONCLUSION: cTnI and Mb are reliable biochemical markers for early diagnosis of AMI and the changes in their serum levels have clinical significance in diagnoses and prognostic judgment of AMI. |
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