| 灯盏花素巴布剂经皮促渗作用研究 |
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| 引用本文： | 李琳,宋西卫,张倩,赵海南,王颖,李楠,刘志东.灯盏花素巴布剂经皮促渗作用研究[J].辽宁中医药大学学报,2012(9):45-47. |
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| 作者姓名： | 李琳 宋西卫 张倩 赵海南 王颖 李楠 刘志东 |
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| 作者单位： | 天津市现代中药重点实验室-省部共建国家重点实验室培育基地;现代中药发现与制剂技术教育部工程研究中心 |
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| 基金项目： | 国家“重大新药创制”科技重大专项项目(2012ZX09304007) |
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| 摘 要： | 目的:考察不同载药量的灯盏花素巴布剂经皮促渗作用。方法:采用透皮扩散仪考察不同载药量灯盏花素巴布剂离体透皮促渗作用;采用微渗析技术考察其在体经皮促渗作用。结果:载药量为1.5%、1.0%、0.5%的灯盏花素巴布剂的体外累计透过量分别为289.15、260.435、158.625μg/cm2;载药量为1.5%、1.0%、0.5%的灯盏花素巴布剂的在体累计透过量分别为8.32、6.53、6.38μg/cm2。结论:灯盏花素巴布剂随着载药量的提高,经皮促渗作用增强,是具有前景的经皮给药载体。
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| 关 键 词： | 灯盏花素 巴布剂 经皮给药 透皮吸收 |
Topical Delivery of Breviscapine-loaded Cataplasma |
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| LI Lin,SONG Xi-wei,ZHANG Qian,ZHAO Hai-nan,WANG Ying,LI Nan,LIU Zhi-dong.Topical Delivery of Breviscapine-loaded Cataplasma[J].Journal of Liaoning University of Traditional Chinese Medicine,2012(9):45-47. |
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| Authors: | LI Lin SONG Xi-wei ZHANG Qian ZHAO Hai-nan WANG Ying LI Nan LIU Zhi-dong |
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| Institution: | 1,2(1.Tianjin State Key Laboratory of Modern Chinese Medicine,Tianjin 300193,China;2.Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique,Tianjin 300193,China) |
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| Abstract: | Objective:To evaluate potential of cataplasma as a topical carrier for enhanced skin permeation of Breviscapine.Method:The in vitro skin permeation behavior was investigated by improved Franz and spread pool;the in vivo skin permeation behavior was investigated by microdialysis.Result:Cumulative amounts of Breviscapine from the content of Breviscapine loaded by cataplasma was 1.5%,1.0%,0.5% and 289.15,260.435,158.625μg/cm2 in vitro,respectively.Cumulative amounts of Breviscapine from the content of Breviscapine loaded by cataplasma was 1.5%,1.0%,0.5% and 8.32,6.53,6.38μg/cm2 in vivo,respectively.Conclusion:Cataplasma provides a good skin permeation effect and may be a promising carrier for topical delivery of Breviscapine. |
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| Keywords: | Breviscapine cataplasma topical delivery percutaneous absorption |
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