| 绿豆癀对四氯化碳所致小鼠急性肝损伤的保护作用 |
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| 引用本文： | 林文泉,刘向国,陈学习,李杰芬.绿豆癀对四氯化碳所致小鼠急性肝损伤的保护作用[J].辽宁中医药大学学报,2013(10):20-21. |
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| 作者姓名： | 林文泉 刘向国 陈学习 李杰芬 |
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| 作者单位： | [1]台湾中医药学会,台湾60054 [2]安徽中医药大学中西医结合临床学院,安徽合肥230038 [3]福建中医药大学,福建福州350108 [4]广州中医药大学,广东广州510405 |
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| 摘 要： | 目的：研究绿豆癀对四氯化碳（CCl4）所致小鼠急性肝损伤的保护作用。方法：用CCl4制作小鼠急性肝损伤模型,绿豆癀和绿豆粉干预,测定血清AST及ALT含量,并作肝组织病理学检测。结果：绿豆癀和绿豆粉能降低小鼠血清AST和ALT的含量（P〈0.01或P〈0.05）;减轻肝细胞变性、坏死程度,缓解肝组织的病理改变,绿豆癀比绿豆粉效果好（P〈0.05）。结论：绿豆癀对CCl4所致小鼠急性肝损伤有保护作用。
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| 关 键 词： | 绿豆癀 四氯化碳 急性肝损伤 保肝作用 |
Protective Effects of Mungbean Huang on Preventing Liver-Damage Caused by CCi4 |
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| Institution: | LIN Wenquan1 , LIU Xiangguo2, CHEN Xuexi3, LI Jlefen ( 1 .Taiwan Association of Chinese Medicine, Taiwan 60054, China ; 2.Department of Integrated Trational Chinese and Western Medicine, Anhui College of Traditional Chinese Medicine, Hefei 230038, Anhui, China; 3.Fujan University of Traditional Chinese Medicine, Fuzhou 350108, Fujan, China; 4.Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong, China ) |
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| Abstract: | Objective ： To study the protective effects of Mungbean Hnang on preventing liver-damage caused by CCI4. Methods ： CC14-induced acute liver injury model was established in mice. After the administration of Mungbean Huang and Munghean powder, the contents of AST and ALT in serum were determined.The liver tissue was selected to observe its pathological changes. Results： Mungbean Huang and Munghean powder could reduce the contents of AST and ALT in serum （ P〈0.01, P〈0.05 ）, and reduce the liver degeneration and extent of necrosis, and improve liver pathological changes distinctly. Mungbean Huang funetioned better than Mungbean powder （ P〈0.05 ）. Conclusion ： Mungbean Huang has protective effects on aeule liver injury of mice induced by CC14. |
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| Keywords: | Mungbean Huang CCI4 acute liver injury hepatoprotection |
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