| 基于双聚类的药物重定位研究热点分析 |
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| 引用本文： | 张庆,轩扬,吕少妮.基于双聚类的药物重定位研究热点分析[J].医学信息学杂志,2019,40(8):72-76. |
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| 作者姓名： | 张庆 轩扬 吕少妮 |
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| 作者单位： | 济宁医学院医学信息工程学院 日照 276826,济宁医学院管理学院 日照 276826,济宁医学院医学信息工程学院 日照 276826 |
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| 摘 要： | 以PubMed收录的药物重定位相关文献为数据来源，提取主要主题词进行频次统计，生成高频主题词-论文矩阵进行聚类分析，结果表明当前药物重定位主要研究热点为基于疾病的药物重定位与基于生物信息学的药物重定位两个方面，具体包括5个主题方向。
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| 关 键 词： | 药物重定位 研究热点 聚类分析 |
| 收稿时间： | 2019/1/18 0:00:00 |
Analysis on Study Hotspots of Drug Repositioning Based on Biclustering |
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| ZHANG Qing,XUAN Yang and LV Shaoni.Analysis on Study Hotspots of Drug Repositioning Based on Biclustering[J].Journal of Medical Informatics,2019,40(8):72-76. |
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| Authors: | ZHANG Qing XUAN Yang and LV Shaoni |
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| Institution: | School of Medical Information Engineering, Jining Medical University, Rizhao 276826, China,School of Management, Jining Medical University, Rizhao 276826, China and School of Medical Information Engineering, Jining Medical University, Rizhao 276826, China |
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| Abstract: | The paper uses literatures related to drug repositioning collected in PubMed as data sources, and extracts major thesauruses to perform frequency count, generates high-frequency thesauruses-literatures matrix to conduct cluster analysis. Results show that the major study hotspots of drug repositioning comprise two bases of diseases and bioinformatics with five subject directions in detail. |
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| Keywords: | drug repositioning study hotspots clustering analysis |
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