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过敏性疾病与肠道菌群失调的相关性及对过敏体质研究的启示
引用本文:杨菲,王济,王琦.过敏性疾病与肠道菌群失调的相关性及对过敏体质研究的启示[J].北京中医药大学学报,2015(8):509-514.
作者姓名:杨菲  王济  王琦
作者单位:北京中医药大学基础医学院中医体质与生殖医学研究中心 北京 100029
基金项目:国家自然科学基金面上项目
摘    要:研究发现过敏性疾病与肠道菌群失调密切相关,其具体机制未明,西医学认为可能与树突状细胞等免疫细胞导致的肠道通透性增高、肠道屏障破坏相关。根据中医理论,可以认为与"肺脏受邪,传于大肠","脾脏受邪,营养受限,微环境骚动"和"肝脏受邪,风气内动,微环境骚动"3个原因相关,根本原因在于"邪气凑之,正气必虚"。结合中医体质学的4个基本原理"生命过程论""形神构成论""环境制约论""禀赋遗传论"探讨肠道菌群研究给中医过敏体质研究带来的启示。

关 键 词:过敏性疾病  食物过敏  肠道菌群  过敏体质  启示

Allergic diseases and intestinal flora imbalance for allergic constitution research
Abstract:Studies have shown that intestinal flora imbalance is closely related with allergic diseases,yet its specific mechanism remains unclear.Modern medicine considers that it may be associated with in-creased intestinal permeability and intestinal barrier disruption caused by dendritic cells and other im-mune cells.Traditional Chinese Medicine identifies three possible approaches,which are “Lungs invaded by evil passing to the large intestine”,“Spleen invaded by evil leading to restricted nutrition and dis-turbed microenvironment”and “Liver invaded by evil leading to stirred-up wind and disturbed microenvi-ronment”.The root cause is that “Pathogenic factor invades when Zheng Qi is deficient”.This paper ex-plores what intestinal flora research can bring to the allergic constitution study by combining the four fun-damental theories “Life course theory”,“Composition of form and spirit”,“Environmental constraint theory”,and “Theory of innate endowment”.
Keywords:allergic diseases  food allergies  intestinal flora  allergic constitution  implications
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