| 中药方剂网络与中药化学空间的构建与分析 |
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| 引用本文： | 龙伟,邳馨,向剑,刘培勋,邹忠梅.中药方剂网络与中药化学空间的构建与分析[J].北京中医药大学学报,2011,34(11):729-732,740. |
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| 作者姓名： | 龙伟 邳馨 向剑 刘培勋 邹忠梅 |
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| 作者单位： | 中国医学科学院北京协和医学院放射医学研究所天津市分子核医学重点实验室 天津300192;中国医学科学院北京协和医学院药用植物研究所 |
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| 摘 要： | 目的 构建中药方剂网络与中药化学空间,在此基础上进行中药方剂网络与化学空间性质的分析,对中药配伍禁忌理论给出解释.方法 利用复杂网络技术,通过Pajek和ORA等软件构建中药方剂网络,并对该方剂网络进行网络直径、平均距离、聚类系数、平均度数等网络性质的分析.在化学空间理论基础上,通过描述符计算、重心处理、空间降维等步骤...
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| 关 键 词： | 中药方剂 复杂网络 化学空间 配伍禁忌 十八反十九畏 |
Network of Chinese medical formulas and Chinese medicinal chemical space |
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| LONG Wei,PI Xin,XIANG Jian,LIU Pei-Xun,ZOU Zhong-Mei.Network of Chinese medical formulas and Chinese medicinal chemical space[J].Journal of Beijing University of Traditional Chinese Medicine,2011,34(11):729-732,740. |
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| Authors: | LONG Wei PI Xin XIANG Jian LIU Pei-Xun ZOU Zhong-Mei |
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| Institution: | LONG Wei1,PI Xin1,XIANG Jian1,LIU Pei-Xun1#,ZOU Zhong-Mei2(1 Tianjin Key Laboratory of Molecular Nuclear Medicine,Institute of Radiation Medicine,Chinese Academy of Medical Sciences and Peking Union Medical College,2 Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences and Peking Union Medical College) |
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| Abstract: | Objective To construct the network of Chinese medical formulas and Chinese medicinal chemical space,and analyze their properties and explain TCM theory of prohibited combination.Methods The network of Chinese medical formulas was built up by using complex network technology and software such as Pajek and ORA.The properties of this network were analyzed including network diameter,average distance,clustering coefficient and average degree.The Chinese medicinal chemical space was constructed through describing... |
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| Keywords: | Chinese medical formulas complex network Pajek chemical space systems biology |
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