| 骤然升温导致脑梗塞发病的血液流变学机制研究 |
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| 引用本文： | 刘晓燕,郭霞珍,杨云霜,李立华.骤然升温导致脑梗塞发病的血液流变学机制研究[J].北京中医药大学学报,2010,33(1):23-27. |
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| 作者姓名： | 刘晓燕 郭霞珍 杨云霜 李立华 |
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| 作者单位： | 北京中医药大学基础医学院,北京,100029;北京中医药大学基础医学院,北京,100029;北京中医药大学基础医学院,北京,100029;北京中医药大学基础医学院,北京,100029 |
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| 基金项目： | 北京市自然科学基金资助项目(No.7072038) |
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| 摘 要： | 目的基于天人相应的理论,探讨气温骤升致高血压大鼠发生脑梗塞血液流变学的相关机制。方法采用易卒中型肾血管性高血压(RHRSP)模型,放置于人工模拟的气温骤升环境中诱发脑梗塞,检测气温骤升前后大鼠血液流变学指标。结果气温骤升时,所有大鼠全血黏度、红细胞聚集、红细胞电泳指数、红细胞压积和红细胞刚性指数均升高,模型组变化幅度最大;升温结束后,生理组、假手术组全血黏度下降,而模型组仍呈上升趋势(P0.05或P0.01),而且模型组升温后的全血黏度、红细胞聚集指数、红细胞电泳指数和红细胞刚性均明显高于同时间点生理组和假手术组(P0.05或P0.01)。结论气温突升导致脑梗塞的发生并不在于升温能导致机体全血黏度的升高,流动性减慢,更在于以高血压为主的长期的病理基础破坏了机体适应环境变化的自我调节能力,使其在高温刺激后血液黏度持续升高而无法恢复正常的生理状态。
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| 关 键 词： | 气温骤升 脑梗塞 天人相应 血液流变学 大鼠 |
Hemorrheology mechanism of cerebral infarction induced by sudden rise of temperature |
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| LIU Xiao-yan,GUO Xia-zhen,YANG Yun-shuang,LI Li-hua.Hemorrheology mechanism of cerebral infarction induced by sudden rise of temperature[J].Journal of Beijing University of Traditional Chinese Medicine,2010,33(1):23-27. |
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| Authors: | LIU Xiao-yan GUO Xia-zhen YANG Yun-shuang LI Li-hua |
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| Institution: | School of Preclinical Medicine/a>;Beijing University of Chinese Medicine/a>;Beijing 100029 |
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| Abstract: | Objective To discuss the hemorrheology mechanism of cerebral infarction induced by sudden rise of temperature in hypertensive rats based on TCM doctrine of correspondence between nature and human.Method The model of stroke-prone renovascular hypertension(RHRSP) was put into artificial circumstance of sudden rise of temperature for inducing cerebral infarction.The changes of hemorrheology indexes were detected before and after the sudden rise of temperature.Result The whole blood viscosity, erythrocyte aggre... |
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| Keywords: | sudden rise of temperature cerebral infarction correspondence between nature and human hemorrheology rats |
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