| 开心散血清HPLC特征图谱研究 |
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| 引用本文： | 巴寅颖,刘洋,姜艳艳,萨础拉,刘倩颖,折改梅,刘斌,石任兵.开心散血清HPLC特征图谱研究[J].北京中医药大学学报,2011,34(6):409-412,416. |
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| 作者姓名： | 巴寅颖 刘洋 姜艳艳 萨础拉 刘倩颖 折改梅 刘斌 石任兵 |
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| 作者单位： | 北京中医药大学中药学院国家中医药管理局中药经典名方有效物质发现重点研究室 北京100102;北京中医药大学中药学院国家中医药管理局中药经典名方有效物质发现重点研究室 北京100102;北京市教委中药质量控制技术工程中心 |
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| 基金项目： | 国家重大新药创制资助项目(No.2009ZX09502-006); 国家“211”工程建设资助项目 |
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| 摘 要： | 目的 建立开心散血清特征图谱,并分析鉴定开心散体内吸收入血化学成分.方法取SD大鼠,灌胃给予开心散及其各单味药水提物,分离含药血清,HPLC法测定,建立开心散以及大鼠口服开心散含药血清的高效液相(HPLC)图谱分析方法；分析开心散全方/单味药及其大鼠含药血清,特征图谱；比对鉴定口服开心散后大鼠血中成分、来源生药及其代谢...
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| 关 键 词： | 开心散 特征图谱 化学成分 血清 大鼠 |
HPLC characteristic chromatograms of serum of Kai Xin San |
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| BA Yin-ying,LIU Yang,JIANG Yan-yan,SA Chu-la,LIU Qian-ying,SHE Gai-mei,LIU Bin,SHI Ren-bing.HPLC characteristic chromatograms of serum of Kai Xin San[J].Journal of Beijing University of Traditional Chinese Medicine,2011,34(6):409-412,416. |
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| Authors: | BA Yin-ying LIU Yang JIANG Yan-yan SA Chu-la LIU Qian-ying SHE Gai-mei LIU Bin SHI Ren-bing |
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| Institution: | BA Yin-ying1,LIU Yang1,2,JIANG Yan-yan1,SA Chu-la1,LIU Qian-ying1,SHE Gai-mei1,LIU Bin1,SHI Ren-bing1,2(1 School of Chinese Pharmacy,Key Unit of Exploring Effective Substances of Classical and Famous Formulas of State Administration of Traditional Chinese Medicine,Beijing University of Chinese Medicine,Beijing 100102,2 Quality Control Technology and Engineering Center of Chinese Medicine,Beijing Municipal Commission of Education) |
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| Abstract: | Objective To establish the characteristic chromatograms of serum of Kai Xin San,and analyze and identify its chemical compositions absorbed into blood.Methods SD rats were orally given Kai Xin San and water extractive of each single ingredient.The medicinal serum were separated and detected with HPLC.The analysis methods of HPLC characteristic chromatograms of Kai Xin San and medicinal serum were established.The characteristic chromatograms of the whole formula of Kai Xin San,single ingredient and medicinal... |
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| Keywords: | Kai Xin San characteristic chromatograms chemical composition serum rats |
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