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川芎嗪对血管紧张素Ⅱ致心肌肥大的影响
引用本文:郭自强,牛福玲,朱陵群,王伟,王硕仁,黄启福.川芎嗪对血管紧张素Ⅱ致心肌肥大的影响[J].北京中医药大学学报,2001,24(3):32-34.
作者姓名:郭自强  牛福玲  朱陵群  王伟  王硕仁  黄启福
作者单位:北京中医药大学东方医院
基金项目:国家中医药管理局重点课题! (No .972 0 6 9)
摘    要:利用体外细胞培养技术 ,观察了川芎嗪对血管紧张素Ⅱ (AngⅡ )致心肌肥大的影响。结果表明 :川芎嗪抑制AngⅡ引起的培养心肌细胞总蛋白含量及直径的增加 ,对AngⅡ引起的心脏成纤维细胞的增殖也有抑制作用 ,其效果与AngⅡ受体 1阻滞剂Losartan相似 ,说明川芎嗪具有抑制心肌肥厚的作用。

关 键 词:川芎嗪  血管紧张素Ⅱ  心肌肥大
修稿时间:2000年12月10日

Effects of Ligustrazine on the Angiotensin Ⅱ-induced Myocardial Hypertrophy
Guo Ziqiang,Niu Fuling,Zhu Lingqun,et al..Effects of Ligustrazine on the Angiotensin Ⅱ-induced Myocardial Hypertrophy[J].Journal of Beijing University of Traditional Chinese Medicine,2001,24(3):32-34.
Authors:Guo Ziqiang  Niu Fuling  Zhu Lingqun  
Abstract:The effects of ligustrazine on the angiotensin Ⅱ-induced myocardial hypertrophy were observed by using the technique of in vitro cell culture. The results showed that ligustrazine could inhibit the angiotensin Ⅱ-induced increase of the content and molecular diameter of the total protein in the cultured myocardial cells and the angiotensin Ⅱ-induced proliferation of the cardiac fibroblasts. The effects of ligustrazine found in this study was similar to those of losartan, which implies that ligustrazine has the effects of inhibiting myocardial hypertrophy.
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