| 党参对大鼠离体工作心脏缺血／再灌注损伤的保护作用 |
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| 引用本文： | 郭自强,朱陵群,张立平,肖和印.党参对大鼠离体工作心脏缺血／再灌注损伤的保护作用[J].北京中医药大学学报,1995(5). |
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| 作者姓名： | 郭自强 朱陵群 张立平 肖和印 |
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| 作者单位： | 北京中医药大学第二附属医院，北京中医药大学病理教研室，北京中医药大学东直门医院 |
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| 摘 要： | 在大鼠离体工作心脏缺血／再灌注损伤模型上，观察党参对缺血／再灌注心脏的保护作用。研究表明党参能提高缺血／再灌注损伤心肌超氧化物歧化酶（ＳＯＤ）活性，降低丙二醛（ＭＤＡ）含量，减少肌酸激酶的释放，使心肌的收缩和舒张功能得到明显改善，并能促进心输出量、冠脉流量、每搏输出量及心率的恢复。提示党参对缺血／再灌注所致的心肌脂质过氧化损伤有一定的保护作用，从而改善心脏的功能。
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| 关 键 词： | 党参 心肌再灌注损伤 血流动力学 心功能 超氧化物歧化酶 丙二醛 肌酸激酶 |
Effects of Radix Codonopsis Pilosukae on Ischemic Reperfusion Injury in Isolated Working Heart of Rats |
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| Guo Ziqiang, Zhu Lingqun, Zhang Liping,et al..Effects of Radix Codonopsis Pilosukae on Ischemic Reperfusion Injury in Isolated Working Heart of Rats[J].Journal of Beijing University of Traditional Chinese Medicine,1995(5). |
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| Authors: | Guo Ziqiang Zhu Lingqun Zhang Liping |
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| Institution: | Guo Ziqiang; Zhu Lingqun; Zhang Liping; et al. |
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| Abstract: | Effects of Radix Codonopsis Pilosulae on ischemic reperfusion injury in isolated working heart of rats were observed. The results showed that the drug enhanced the activity of the myocardial superoxide dismutase (SOD), decreased the content of the myocardial malindialdehyd (MDA) and reduced the creatine kinase (CK) release. At the same time, the drug also improved significantly the contractile function (AP, LVSP, +dp/dtmax) and diastolic function (-dp/dtmax, LVEDP,T),as well as recovered the CO,CF, SV and HR of the isolated working heart of rats. It is suggested that the protective effects of Radix Codonopsis Pilosulae on myocardial function during ischemic reperfusion injury might be due to their antilipid peroxidative inJury. |
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| Keywords: | Radix Codonopsis Pilosulae Myocardial reperfusion injury Hemodynamics Cardiac function Superoxide dismutase Malondialdehyde Creatine kinase |
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