利用脑电非线性分析关联维数对肝气郁结证患者的研究

目的探讨肝气郁结证患者脑电非线性动力学变化规律。方法15例肝气郁结症患者和15例正常受试者按年龄、性别配对,用参数D2对安静闭眼、安静睁眼、睁眼心算3种状态下的脑电数据进行分析。结果肝气郁结证患者部分区域的D2较正常人增高,随刺激条件的增加,肝气郁结证患者与正常人大脑皮层的D2均增高,但两者之间D2差异逐渐缩小,肝气郁结证患者有认知功能的改变。结论脑电非线性分析相对客观和准确地观测到肝气郁结证患者皮层的变化,可以用来对肝气郁结证的脑机制进行研究。

Study on patients with syndrome of liver-qi stagnation by using correlative dimension of non-linear analysis of electroencephalogram

Objective To investigate the change law of non-linear dynamic characteristics of electroencephalogram(EEG) in the patients with the syndrome of stagnation of liver-qi.Methods The patients with the syndrome of stagnation of liver-qi(group 1,n=15) and normal persons(group 2,n=15) were paired according to the sex and age.The data of EEG were analyzed under three conditions(eye closed,eye opened and mental arithmetic with eye opened) by the parameter of correlation dimension(D2).Results The data of D2 in parts of brain zone in group 1 increased significantly than those in group 2.The data of D2 in the cortex in two groups all increased along with the enhancement of stimulation,but the difference in D2 between two groups was reduced gradually.Group 1 had some changes in cognitive function.Conclusion The non-linear dynamic characteristics of EEG reflects objectively and accurately the cortex changes in the patients with the syndrome of stagnation of liver-qi,and it can be used for the study on the cerebral mechanism of the syndrome of stagnation of liver-qi.