| 生化标志物的检测对判定急性心肌梗死溶栓后冠脉再通的临床价值 |
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| 引用本文： | 李挺,伍华,黄杰雄,何慧娟.生化标志物的检测对判定急性心肌梗死溶栓后冠脉再通的临床价值[J].热带医学杂志,2009,9(1). |
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| 作者姓名： | 李挺 伍华 黄杰雄 何慧娟 |
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| 作者单位： | 肇庆市第一人民医院心血管内科,肇庆,526021 |
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| 摘 要： | 目的研究检测生化标志物血清肌红蛋白(MYO)、肌钙蛋白I(cTnI)、肌酸激酶同工酶(CK-MB)和C-反应蛋白(CRP)对急性心肌梗死溶栓冠脉再通的早期诊断价值。方法MYO、cTnI、CK-MB使用酶联免疫分析法、CRP使用激光散射比浊法测定127例急性心肌梗死患者溶栓治疗前后MYO、cTnI、CK-MB和CRP浓度和时间的变化,分析急性心肌梗死患者溶栓再通组(83例)和溶栓未通组(44例)上述指标的连续、动态演变。结果急性心肌梗死溶栓再通组MYO、cTnI、CK-MB和CRP达到峰值浓度的时间较未通组明显提前(P<0.01),其中MYO较cTnI、CK-MB和CRP峰值时间出现更早,分别为(6.1±2.4)h、(13.8±3.5)h、(14.4±3.8)h和(25.2±5.7)h(P<0.01);再通组MYO和CRP峰值浓度明显高于未通组(P<0.01);MYO、cTnI、CK-MB和CRP对判断冠脉再通的敏感性、特异性、预测值差异无统计学意义(P>0.05)。结论血清MYO、cTnI、CK-MB和CRP可以较好地预测急性心肌梗死患者溶栓再通,其中MYO较cTnI、CK-MB和CRP能更早期判断冠状动脉是...
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| 关 键 词： | 急性心肌梗死 肌红蛋白 肌钙蛋白I 肌酸激酶同工酶 C-反应蛋白 溶栓 |
Clinical Values of Biochemical Markers on Early Diagnosis of Coronary Recanalization in Acute Myocardial Infarction after Coronary Thrombolysis |
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| LI Ting,WU Hua,HUANG Jie-xiong,HE Hui-juan.Clinical Values of Biochemical Markers on Early Diagnosis of Coronary Recanalization in Acute Myocardial Infarction after Coronary Thrombolysis[J].Journal Of Tropical Medicine,2009,9(1). |
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| Authors: | LI Ting WU Hua HUANG Jie-xiong HE Hui-juan |
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| Institution: | Department of Cardiovascular;the First Hospital of Zhaoqing City;Zhaoqing 526021;China |
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| Abstract: | Objective To study the early diagnostic value of serum markers myoglobin(MYO),troponin I(cTnI),creatine kinase-MB(CK-MB) and C-reactive protein(CRP) for coronary recanalization in acute myocardial infarction after coronary thrombolysis.Methods MYO,cTnI,CK-MB were detected by enzyme-linked immunoassay(ELISA) and CRP was measured by laser scat tering turbidimetry.Among 127 acute myocardial infarction patients,changes in the concentrations of MYO,cTnI,CK-MB and CRP were recorded before and after thrombolysis.D... |
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| Keywords: | acute myocardial infarction myoglobin troponin I creatine kinase-MB C-reactive protein thrombolysis |
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