盐酸纳络酮治疗急性脑梗死的临床研究

目的观察盐酸纳络酮治疗急性脑梗死的临床疗效.方法选择发病在72h内的急性脑梗死患者共182例,随即分为治疗组和对照组.治疗组给予5%葡萄糖或生理盐水250ml 纳络酮2mg静脉点滴,每日一次,共用14d.对照组给予低分子右旋糖酐500ml静脉点滴,每日一次,共用14d.治疗前后均进行神经功能缺损评分,然后对照.结果治疗组98例治疗前后比较,神经缺损明显改善,总有效率达82.65%,对照组总有效率为51.19%,两组相比有显著差异P＜0.05,特别是对中、重型患者治疗组与对照组相比疗效更显著.结论盐酸纳络酮是治疗急性脑梗死的安全、有效药物.

Clinical Study of the Effect of Naloxone Hydrochloride on the Treatment of Acute Cerebral Infarction

Objective To observe the clinical effect of naloxone hydrochloride on the treatment of acute cerebral infarction. Methods 182 patients who showed the acute cerebral infarction within 72 hours were chosen and then randomly divided into treatment group and control group. The patients in treatment group were treated by intravenous injection with 250ml of 5% glucose solution or of normal saline with 2mg naloxone hydrochloride, once per day, and continued for 14 days. The patients in control group had been injected with 500ml of low molecular dextran, once per day and for 14 days. The impairment of the nerve function was evaluated before and afer treatment and compared with that of the control group in these two groups. Results In the treatment group, 98 patients (82.65%) showed an obvious improvement in nerve functions after treatment, while in the control group only 51.19% showing an improvement. There is a significant different between these two groups(P<0.05). Patients with moderate and serve symptom showed greater improvement. Conclusion Naloxone hydrochloride is the safe and effective medicine to cure the acute cerebral infarction.